PMID: 3772296Nov 1, 1986Paper

Extracellular matrix-modulated expression of human cell surface glycoproteins A42 and J143. Intrinsic and extrinsic signals determine antigenic phenotype

The Journal of Experimental Medicine
W J RettigL J Old

Abstract

We have used serologic, biochemical, and genetic methods to characterize two stage-specific human differentiation antigens of neural and melanocytic cells: A42 (57,000 Mr glycoprotein) and J143 (140,000/30,000 Mr glycoprotein). The genes determining A42 and J143 cell surface expression in rodent-human hybrids were chromosomally mapped, and the respective human chromosomes were introduced into rodent cells derived from distinct differentiation lineages. Serologic analysis of the resulting hybrid clones has permitted the identification of two types of regulatory signals determining A42 and J143 expression. First, both antigens are expressed in hybrids constructed with antigen-positive human cells and also in certain hybrids constructed with antigen-negative human cells, indicating that intrinsic signals provided by the differentiation program of the rodent fusion partner induce antigen expression. Second, a series of human-mouse neuroblastoma hybrids, which are A42- or J143- when cultured on plastic surfaces, can be induced to express the antigens when cultured on substrates coated with extracellular matrix (ECM) produced by bovine corneal endothelial cells or fibronectin. This induction of antigen expression by extrinsic, ECM-de...Continue Reading

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Citations

Jun 1, 1991·Cancer Metastasis Reviews·S A LynchA N Houghton
Apr 1, 1988·Immunology Today·M E Hemler
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·W J RettigL J Old
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M De LucaV Quaranta
Mar 1, 1990·The Journal of Cell Biology·H LarjavaK M Yamada
Dec 1, 1991·Scandinavian Journal of Immunology·D G StupackJ A Wilkins
Jan 27, 1989·Cell·L C Plantefaber, R O Hynes
Apr 22, 1993·International Journal of Cancer. Journal International Du Cancer·P G NataliA Bigotti
Aug 15, 1994·International Journal of Cancer. Journal International Du Cancer·A BartolazziP G Natali

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