PMID: 15224884Jul 1, 2004Paper

Extracellular matrix of Reinke's space in some pathological conditions

Acta Oto-laryngologica
Santa Vecerina VolićTihana Ibrahimpasić

Abstract

Reinke's space (RS) is a highly specific structure in which the majority of vocal fold pathology occurs. The vibratory equivalents of structurally normal RS are regular vocal fold vibrations and normal glottic mucosal waves. Recently, RS has been considered to be composed not only of fibres but also of extracellular matrix (ECM), which is an extremely important component of a normal mucosal wave. As Reinke's oedema (RO) is characterized by excessive ECM in RS, we investigated the cell activity in RO tissue which is possibly responsible for excessive ECM production. Tissue samples were obtained from 20 RO patients during microlaryngeal surgery. Tissue was analysed histochemically using the AgNOR method and the proliferation activity was assessed immunohistochemically using Ki67 monoclonal antibodies. AgNOR activity was detected in prominent stromal cells in 16 patients. Also, more pronounced activity, compared to the surrounding control tissue, was demonstrated in the epithelial cells of 17 patients using a Ki67 proliferation marker. Electron microscopy showed thickening and decomposition of the basement membrane in all RO tissue samples. Vocal fold mucosa that has been damaged by smoking and phonotrauma may react by producing e...Continue Reading

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Citations

Sep 8, 2010·European Journal of Histochemistry : EJH·M ArticoM De Vincentiis
Aug 28, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Erdogan OkurAli Altuntaş
Jun 10, 2008·Journal of Voice : Official Journal of the Voice Foundation·Mara BehlauPaulo Pontes
Mar 28, 2006·Journal of Voice : Official Journal of the Voice Foundation·Milan B JovanovicSlobodan Malobabic
Mar 19, 2008·Journal of Voice : Official Journal of the Voice Foundation·Milan B JovanovicSlobodan Malobabic
Jul 28, 2016·Journal of Voice : Official Journal of the Voice Foundation·Regina Helena Garcia MartinsAdriana Bueno Benito Pessin
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Oct 12, 2013·The Laryngoscope·Lucio Díaz-FloresDaniel López-Campos
Sep 7, 2018·The Annals of Otology, Rhinology, and Laryngology·Raluca TavalucMelin Tan
Jun 6, 2008·The Laryngoscope·Flavio Akira SakaeDomingos H Tsuji
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Jan 26, 2010·Journal of Voice : Official Journal of the Voice Foundation·Regina Helena Garcia MartinsRafael de Albuquerque e Silva

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