Extracellular matrix protein 1 recruits moesin to facilitate invadopodia formation and breast cancer metastasis

Cancer Letters
Qiuwan WuZhongquan Qi

Abstract

Invadopodia are actin-based cortical protrusions of tumour cells, and required for stromal invasion and metastasis. Extracellular matrix protein 1 (ECM1) has long been regarded as a secretory protein, but the mechanism of its precise functions in tumour cells is still obscure. Recently published data suggested a function of ECM1 in remodelling the actin cytoskeleton; however, its role in invadopodia formation remains unknown. Here, we demonstrated for the first time that ECM1 was a membrane protein and was essential for invadopodia formation by breast cancer cells. ECM1 depletion attenuated the ability of tumour cells to matrix attachment, invasion, and spontaneous metastasis to the lungs of mice. Additionally, co-expression of ECM1 and moesin (MSN) was closely related to aggressive breast cancer phenotypes. ECM1 interacted with MSN and recruited it adjacent to the membrane in order to promote MSN membrane translocation and phosphorylation, which facilitated invadopodia formation by breast cancer cells. These results elucidate a novel mechanism underlying the role of ECM1 in breast cancer metastasis and suggest ECM1 as a potential therapeutic target for overcoming tumour dissemination.

Citations

Jan 26, 2020·Proceedings of the National Academy of Sciences of the United States of America·Yaguang ZhangBing Sun
Mar 24, 2020·Laboratory Investigation; a Journal of Technical Methods and Pathology·Sophie Sarah SteinhaeuserThorarinn Gudjonsson
Oct 8, 2020·Cell Death & Disease·Cuixia YangFeng Gao
Apr 6, 2021·Frontiers in Oncology·Xin JiangYanhong Zhou
Jun 22, 2021·Scandinavian Journal of Gastroenterology·Cheng DingMenghua Dai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.