Extracellular matrix protein DMP1 suppresses osteogenic differentiation of Mesenchymal Stem Cells

Biochemical and Biophysical Research Communications
Shufan ZhangYao Sun

Abstract

Mesenchymal Stem Cells (MSCs) are self-renewing and multipotent stem cells which was investigated for diverse clinical applications. However, complex mechanism of MSCs fate determination is still not fully disclosed. Extracellular matrix (ECM) proteins contribute to maintain MSCs stemness by providing extracellular microenvironment. Increasing evidences show that ECM proteins could also regulate the fate of MSCs directly. Dentin matrix protein 1 (DMP1) is an ECM protein enrich in bone tissue and terminal cells, which well-known in promoting osteoblasts and osteocytes maturation, and facilitate mineralization. Recently, our experiment indicated that DMP1 was also expressed in MSCs of long bone. In present study, it is found that DMP1 expressed in Prx1 positive MSCs. And, DMP1 is down-regulated in early osteoblasts and up-regulated again in mature osteoblasts. DMP1 conditional knockout mice model under Prx1cre was generated to explore whether DMP1 regulates MSCs osteogenic differentiation. Specific ablation of DMP1 in Prx1 positive MSCs increased bone mass in vivo and promoted osteoblasts activity in vitro. This study provides a new understanding of DMP1's function in regulation of osteogenesis: not only an enhancer of bone forma...Continue Reading

Citations

Aug 29, 2019·Journal of Oral Rehabilitation·Mingxiang CaiYao Sun
Jul 6, 2019·Current Medicinal Chemistry·Shuaimeng GuanJingan Li
Aug 6, 2020·Frontiers in Cell and Developmental Biology·Anastasiia D KurenkovaAndrei S Chagin
Jun 13, 2020·Frontiers in Pharmacology·Xiao LinAirong Qian
Oct 24, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yubei ChenYao Sun

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