Extracellular matrix protein expression is brain region dependent

The Journal of Comparative Neurology
Stephanie DauthKevin Kit Parker

Abstract

In the brain, extracellular matrix (ECM) components form networks that contribute to structural and functional diversity. Maladaptive remodeling of ECM networks has been reported in neurodegenerative and psychiatric disorders, suggesting that the brain microenvironment is a dynamic structure. A lack of quantitative information about ECM distribution in the brain hinders an understanding of region-specific ECM functions and the role of ECM in health and disease. We hypothesized that each ECM protein as well as specific ECM structures, such as perineuronal nets (PNNs) and interstitial matrix, are differentially distributed throughout the brain, contributing to the unique structure and function in the various regions of the brain. To test our hypothesis, we quantitatively analyzed the distribution, colocalization, and protein expression of aggrecan, brevican, and tenascin-R throughout the rat brain utilizing immunohistochemistry and mass spectrometry analysis and assessed the effect of aggrecan, brevican, and/or tenascin-R on neurite outgrowth in vitro. We focused on aggrecan, brevican, and tenascin-R as they are especially expressed in the mature brain, and have established roles in brain development, plasticity, and neurite outg...Continue Reading

References

Dec 1, 1994·Journal of Neurology·J Silver
Jan 1, 1994·Brain Research. Brain Research Reviews·M R Celio, I Blümcke
Jan 9, 1999·Trends in Neurosciences·M R CelioL Vitellaro-Zuccarello
May 20, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S A SchnellM W Wessendorf
Aug 16, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·B K Lipska, D R Weinberger
Nov 15, 2000·The Journal of Comparative Neurology·G BrücknerM Schachner
Feb 13, 2001·Experimental Neurology·I Sellés-NavarroL McKerracher
Sep 8, 2001·Progress in Brain Research·R A AsherJ W Fawcett
Apr 12, 2002·Nature·Elizabeth J BradburyStephen B McMahon
Oct 18, 2002·Arthritis and Rheumatism·William E B JohnsonSally Roberts
Aug 19, 2004·Cellular and Molecular Life Sciences : CMLS·U Rauch
Jun 7, 2005·Molecular and Cellular Neurosciences·Ryan J GilbertRavi V Bellamkonda
Jul 22, 2006·Nature Reviews. Neuroscience·Elizabeth J Bradbury, Stephen B McMahon
Oct 13, 2006·Trends in Neurosciences·Binhai ZhengFang Xie
Apr 20, 2007·Developmental Neurobiology·Alexander DityatevMelitta Schachner
Jun 15, 2007·The European Journal of Neuroscience·Sabrina ReimersSteffen Rossner
Nov 3, 2007·Cellular and Molecular Life Sciences : CMLS·R R Gonzenbach, M E Schwab
Jul 10, 2008·The Journal of Biological Chemistry·Bin HuMariano S Viapiano
Jul 30, 2008·Brain Pathology·Dafna Bonneh-Barkay, Clayton A Wiley
Aug 13, 2008·Histochemistry and Cell Biology·Dieter R Zimmermann, María T Dours-Zimmermann
Apr 21, 2009·Nature Methods·Jacek R WiśniewskiMatthias Mann
Oct 9, 2009·Journal of Tissue Engineering and Regenerative Medicine·Emma EastJames B Phillips
Jul 22, 2010·Epilepsia·Alexander Dityatev
Aug 25, 2010·Neuroscience·K A GiamancoR T Matthews
Oct 15, 2010·Nature Reviews. Neuroscience·Alexander DityatevPeter Sonderegger
Jul 8, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Susanne A GatzPenny A Jeggo
Aug 23, 2011·Neuropharmacology·Sabina Berretta
Sep 8, 2011·Developmental Neurobiology·Jessica C F KwokJames W Fawcett
Feb 3, 2012·The International Journal of Biochemistry & Cell Biology·M MorawskiR T Matthews

❮ Previous
Next ❯

Citations

Apr 27, 2016·Biological Psychiatry·Byron K Y BitanihirweTsung-Ung W Woo
May 29, 2016·Journal of Chemical Neuroanatomy·Matthew T K Kirkcaldie, Jessica M Collins
Sep 8, 2016·Analytical and Bioanalytical Chemistry·Manveen K Sethi, Joseph Zaia
Sep 2, 2016·Alcoholism, Clinical and Experimental Research·Amy W Lasek
Apr 13, 2018·International Journal of Molecular Sciences·Sian F Irvine, Jessica C F Kwok
May 22, 2018·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·May J ReedRobert B Vernon
Dec 19, 2017·Frontiers in Integrative Neuroscience·Heleen M van 't Spijker, Jessica C F Kwok
Oct 30, 2018·Journal of Alzheimer's Disease : JAD·M Mahafuzur RahmanMats Sandgren
Jul 3, 2019·Nature Reviews. Neuroscience·James W FawcettTommaso Pizzorusso
Oct 2, 2019·The Journal of Comparative Neurology·Lindsay N Collins, Peter C Brunjes
Dec 27, 2017·The Journal of Comparative Neurology·Nichole L Beebe, Brett R Schofield
Apr 18, 2019·Cellular Oncology (Dordrecht)·Pinar Eser OcakJohn H Zhang
Oct 22, 2019·Frontiers in Oncology·Caleb A Stine, Jennifer M Munson
Jun 6, 2019·Cellular and Molecular Life Sciences : CMLS·Sameeksha ChopraAntoine Dufour
Feb 19, 2020·Journal of Neuroinflammation·Marta Moreno-RodriguezElliott J Mufson
Aug 1, 2020·Scientific Reports·Rekha RaghunathanJoseph Zaia
May 10, 2019·Frontiers in Neuroscience·Lavida R K Brooks, George I Mias
Sep 28, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jordan M Blacktop, Barbara A Sorg
Apr 9, 2019·Open Biology·Katherine R Long, Wieland B Huttner
Oct 7, 2020·Brain : a Journal of Neurology·Polyxeni NikolakopoulouAnna Herland
Jan 26, 2021·Frontiers in Immunology·Fritz G Rathjen, Russell Hodge
Jan 1, 2018·Trends in Genetics : TIG·Amy W LasekWei-Yang Chen
Dec 1, 2020·Biochimica Et Biophysica Acta. General Subjects·Kei SugitaniShinji Miyata
Apr 23, 2021·Neurochemistry International·Janko KajtezJenny Emnéus
Jun 28, 2021·Brain Structure & Function·Ellie A BucherMatthew T K Kirkcaldie
Aug 12, 2021·Nature Reviews. Neuroscience·Julien G RothSarah C Heilshorn
Aug 21, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Julian Guarque-ChabreraMarta Miquel
Sep 30, 2021·Biomedical Materials·Wenyu KongYanan Du

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.