Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration.

Blood
Ayako Nakamura-IshizuYoshiaki Kubota

Abstract

The BM microenvironment is required for the maintenance, proliferation, and mobilization of hematopoietic stem and progenitor cells (HSPCs), both during steady-state conditions and hematopoietic recovery after myeloablation. The ECM meshwork has long been recognized as a major anatomical component of the BM microenvironment; however, the molecular signatures and functions of the ECM to support HSPCs are poorly understood. Of the many ECM proteins, the expression of tenascin-C (TN-C) was found to be dramatically up-regulated during hematopoietic recovery after myeloablation. The TN-C gene was predominantly expressed in stromal cells and endothelial cells, known as BM niche cells, supporting the function of HSPCs. Mice lacking TN-C (TN-C(-/-)) mice showed normal steady-state hematopoiesis; however, they failed to reconstitute hematopoiesis after BM ablation and showed high lethality. The capacity to support transplanted wild-type hematopoietic cells to regenerate hematopoiesis was reduced in TN-C(-/-) recipient mice. In vitro culture on a TN-C substratum promoted the proliferation of HSPCs in an integrin α9-dependent manner and up-regulated the expression of the cyclins (cyclinD1 and cyclinE1) and down-regulated the expression of...Continue Reading

References

Mar 1, 1993·Journal of Clinical Pathology·Y SoiniV P Lehto
Apr 29, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S K NilssonP S Becker
Dec 18, 1998·The Journal of Investigative Dermatology·Y KoyamaM Kusakabe
Feb 27, 1999·Journal of Theoretical Biology·E A GaffneyS Tuft
Dec 11, 1999·Virchows Archiv : an International Journal of Pathology·T YoshidaT Sakakura
Dec 5, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·P L Jones, F S Jones
Oct 24, 2003·Nature·L M CalviD T Scadden
Jun 4, 2005·The Journal of Biological Chemistry·Henry C Hsia, Jean E Schwarzbauer
Sep 7, 2005·Statistics in Medicine·Theodore R Holford
Feb 24, 2006·Nature Reviews. Immunology·Anne Wilson, Andreas Trumpp
Apr 1, 2006·Science·Kateri A Moore, Ihor R Lemischka
Jul 20, 2006·British Journal of Haematology·David N Haylock, Susan K Nilsson
Dec 1, 2007·Biochemical and Biophysical Research Communications·Yoshiaki KubotaToshio Suda
Apr 29, 2009·The Journal of Experimental Medicine·Yoshiaki KubotaToshio Suda
May 1, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Melissa R AndrewsJames W Fawcett
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masashi KanayamaToshimitsu Uede
Oct 22, 2009·American Journal of Respiratory Cell and Molecular Biology·Maud M GuedersDidier D Cataldo
Aug 13, 2010·Nature·Simón Méndez-FerrerPaul S Frenette

❮ Previous
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Citations

Nov 13, 2012·Current Opinion in Rheumatology·Dirk Hubmacher, Suneel S Apte
Jan 17, 2014·Nature·Sean J Morrison, David T Scadden
Aug 8, 2014·Nature Medicine·Avital Mendelson, Paul S Frenette
Aug 22, 2013·Cell and Tissue Research·Nicole BrösickeAndreas Faissner
Aug 7, 2014·International Journal of Hematology·Ayako Nakamura-Ishizu, Toshio Suda
Oct 3, 2013·Experimental Hematology·Sarah L EllisSusan K Nilsson
Mar 25, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sogol Mostoufi-MoabMary B Leonard
Nov 28, 2015·Matrix Biology : Journal of the International Society for Matrix Biology·Silvia SmaldoneFrancesco Ramirez
Nov 28, 2013·Scientific Reports·Meghan O AltmanWeihong Tan
Jan 19, 2016·Journal of Biomedical Materials Research. Part a·Xiaobing HuangLingling Wei
Mar 29, 2016·The Journal of Clinical Investigation·Takashi YokoyamaTakuro Nakamura
Nov 11, 2015·The Journal of Experimental Medicine·Ayako Nakamura-IshizuToshio Suda
Jan 30, 2014·Matrix Biology : Journal of the International Society for Matrix Biology·Ruth Chiquet-EhrismannKim S Midwood
Jan 15, 2014·Biochimica Et Biophysica Acta·Francesca GattazzoPaolo Bonaldo
Mar 5, 2015·Cell Adhesion & Migration·Camille M Lowy, Thordur Oskarsson
Sep 13, 2012·Biochimica Et Biophysica Acta·Ayako Nakamura-Ishizu, Toshio Suda
Jun 10, 2015·The International Journal of Biochemistry & Cell Biology·Richard P Tucker, Ruth Chiquet-Ehrismann
Jan 27, 2015·Matrix Biology : Journal of the International Society for Matrix Biology·Gerd KleinWilhelm K Aicher
Jan 24, 2017·Journal of Cellular Biochemistry·Mélanie J DominguesSusan K Nilsson
Apr 5, 2017·Current Opinion in Hematology·Miguel Ganuza, Shannon McKinney-Freeman
Jan 1, 2012·Journal of Functional Biomaterials·Hua MeiSophie X Deng
Feb 1, 2018·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Anna M Marzeda, Kim S Midwood
Oct 7, 2017·Annals of the New York Academy of Sciences·Yaxian ZhouWan-Ju Li
Sep 12, 2017·Journal of Tissue Engineering·Patricia A RedondoUmber Cheema
Jan 22, 2019·Nature Cell Biology·Patrick CarlsonCyrus M Ghajar
Dec 17, 2017·American Journal of Hematology·Orly LeivaKatya Ravid
Oct 3, 2019·Open Biology·Unnikrishnan SivanAnjali P Kusumbe
Aug 28, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Junyu ChenAnjali P Kusumbe
Jun 8, 2017·Cellular and Molecular Life Sciences : CMLS·Giovanna Tosato
Jun 2, 2020·Frontiers in Endocrinology·Andrea Benova, Michaela Tencerova
Jul 2, 2016·Calcified Tissue International·Clarissa S Craft, Erica L Scheller
Aug 29, 2017·The Journal of Clinical Investigation·Ioannis MitroulisTriantafyllos Chavakis
May 16, 2017·Cancer Immunology, Immunotherapy : CII·Sabina SangalettiMario P Colombo
Jan 4, 2018·Blood Advances·Cesar Nombela-Arrieta, Markus G Manz
May 11, 2019·Stem Cells International·Kshitiz Raj Shrestha, So Young Yoo
Apr 1, 2019·Cancer Reports·Travis NemkovJulie A Reisz
Aug 26, 2017·Scientific Reports·Sara Rolandsson EnesGunilla Westergren-Thorsson

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