Mar 25, 2020

Extracellular matrix proteins involved in Alzheimer's disease

Chemistry : a European Journal
Jun MaHongjie Zhang

Abstract

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases and characterized by cognitive and memory impairments. Emerging evidence suggests that the extracellular matrix (ECM) biomacromolecules in brain plays an important role in etiology of AD. It has been detected that the levels of ECM proteins have been changed in the brains of AD patients and animal models. Some ECM components, e.g., elastin and heparan sulfate proteoglycans, are considered to promote the upregulation of extracellular amyloid-β (Aβ) proteins. In addition, collagen VI and laminin are shown to have interactions with Aβ peptides, which might lead to clearance of those peptides. Thus, ECM proteins are involved in both amyloidosis and neuroprotection in AD process. However, the molecular mechanism of neuronal ECM proteins on pathophysiology of AD remains elusive. More investigation of ECM proteins with AD pathogenesis is needed, and this may lead to novel therapeutic strategies and biomarkers for AD.

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Mentioned in this Paper

Extracellular
Neurons
Heparan Sulfate Proteoglycans
Up-Regulation (Physiology)
Neuroprotection
Extracellular Matrix Proteins
Brain
Peptides
Alzheimer's Disease
Biological Markers

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