Extracellular matrix remodeling in hepatocellular carcinoma: effects of soil on seed?

Medical Hypotheses
Xiong-Zhi WuGuang Ru Xie

Abstract

Extracellular matrix plays two-edged roles, inhibitor and promoter, in the carcinogenesis and progression of hepatocellular carcinoma. On the one hand, extracellular matrix provides the survival signals, and controls the proliferation, differentiation and metastasis of hepatocellular carcinoma. On the other hand, hepatocarcinoma cells create a permissive soil by extracellular matrix remodeling, result in high proliferation, low differentiation, apoptosis block, invasion and metastasis. These malignant phenotypes are related with the change of the capsule around hepatocarcinoma cells that composed by collagens I and IV, the cell-extracellular matrix interaction induced by laminin and its receptor-integrins, and the degradation of ECM which is regulated by proteolytic enzymes and their inhibitor. Thus, normalization of ECM may represent a novel therapeutic strategy for hepatocarcinoma cells.

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Citations

Apr 4, 2008·Pathology Oncology Research : POR·Erzsébet SzabóAndrás Kiss
Oct 21, 2011·Lab on a Chip·Elisabetta PrimiceriGiuseppe Maruccio
Jul 11, 2006·Journal of Gastroenterology and Hepatology·Xiong-Zhi Wu, Dan Chen
Jan 19, 2010·World Journal of Gastroenterology : WJG·Shuo Dong, Xiong-Zhi Wu
Feb 18, 2014·European Journal of Pharmacology·Ahmed TayelMohammed M H Al-Gayyar
Sep 26, 2014·Cancer Investigation·Alessandro AllegraCaterina Musolino
Jan 17, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Xue ZhangHongqi Zhang
Feb 16, 2007·Medical Hypotheses·Xiong-Zhi Wu, Xiao-Hui Yu
Nov 22, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Jian-Min YangZai-Yuan Ye
Jul 1, 2016·Journal of Food and Drug Analysis·Aziz Mahmoudzadeh, Hemn Mohammadpour
Jan 28, 2021·International Journal of Molecular Sciences·Luca BedonMaurizio Polano

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