Extracellular modifications of HDL in vivo and the emerging concept of proteolytic inactivation of preβ-HDL

Current Opinion in Lipidology
Miriam Lee-Rueckert, Petri T Kovanen

Abstract

Both quantity and quality of the circulating HDL particle matter for the optimal antiatherogenic potential of HDL. This review summarizes various mechanisms capable of inducing extracellular modifications of HDL and reducing the function of HDL subclasses as cholesterol acceptors. Special emphasis is laid on the proteolytic inactivation of lipid-poor preβ-migrating HDL (preβ-HDL). HDL particles can undergo functional inactivation in vivo. During atherogenesis, different cell types in the arterial intima release enzymes into the intimal fluid, potentially capable of causing structural and chemical modifications of the various components present in the lipid core or in the polar surface of the HDL particles. Enzymatic oxidation, lipolysis and proteolysis, and nonenzymatic glycosylation are among the HDL modifications that adversely affect HDL functionality. Proteolysis of preβ-HDL by various proteases present in the arterial intima has emerged as a potential mechanism that impairs the efficiency of HDL to promote cholesterol efflux from macrophage foam cells, the mast cell-derived neutral protease chymase being a prime example of such impairment. A paradigm of proteolytic inactivation of preβ-HDL in vivo is emerging. Several extr...Continue Reading

References

Nov 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M LeePetri T Kovanen
Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·Y NaganoT Kita
Feb 1, 1990·The Biochemical Journal·E CocuzziS I Chung
Jan 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·S T KunitakeJohn P Kane
Dec 22, 1999·Immunopharmacology·M CerfK Bhoola
Jun 6, 2000·The Journal of Infectious Diseases·W KhovidhunkitC Grunfeld
Nov 4, 2000·Biochemical and Biophysical Research Communications·Leena Lindstedt, Petri T Kovanen
Jan 9, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·K L OlinAlan Chait
Dec 17, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Miriam LeePetri T Kovanen
Feb 26, 2003·Metabolism: Clinical and Experimental·G FerrettiG Curatola
May 29, 2003·Circulation·Clare M DolleryPeter Libby
Dec 4, 2003·Biochemical and Biophysical Research Communications·Leena LindstedtPetri T Kovanen
Mar 23, 2004·The Journal of Biological Chemistry·Márcia Almeida LizMónica Mendes Sousa
Aug 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·Constanze BergtJay W Heinecke
Sep 11, 2004·Biochemical and Biophysical Research Communications·John A StonikH Bryan Brewer
Mar 3, 2007·The Journal of Clinical Investigation·Tomas VaisarJay W Heinecke
May 16, 2007·Circulation·Peter Libby, Guo-Ping Shi
Jun 15, 2007·Annals of Medicine·Ivano EberiniCesare R Sirtori
Aug 19, 2007·Journal of Lipid Research·Márcia Almeida LizMónica Mendes Sousa
Feb 8, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Miriam Lee-RueckertPetri T Kovanen
Jun 3, 2008·Journal of Lipid Research·Michael J ThomasMary G Sorci-Thomas
Nov 15, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Anisa JahangiriFrederick C de Beer
Dec 10, 2008·Journal of Lipid Research·Daniel J RaderGeorge H Rothblat
May 7, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Guadalupe Ortiz-MuñozOlivier Meilhac
May 26, 2009·Archives of Biochemistry and Biophysics·Sandrine ChantepieAnatol Kontush
Jun 3, 2009·Nature Reviews. Cardiology·Danielle Duffy, Daniel J Rader
Jul 18, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Mohamad NavabAlan M Fogelman
Sep 26, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Pia DavidssonGermán Camejo
Jan 30, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Estelle NobécourtKerry-Anne Rye
Mar 5, 2010·Current Pharmaceutical Design·Illiana MeursTheo Jc Van Berkel
Mar 18, 2010·Blood·Gunnar PejlerSara Wernersson
May 19, 2010·Current Opinion in Lipidology·George H Rothblat, Michael C Phillips
Aug 13, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Miriam Lee-RueckertPetri T Kovanen
Nov 26, 2010·Biochemical and Biophysical Research Communications·Angela PirilloAlberico L Catapano
Dec 17, 2010·Journal of Lipid Research·Denys BashtovyyJere P Segrest
Jan 8, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Miriam Lee-RueckertJoan Carles Escola-Gil
Jan 14, 2011·The New England Journal of Medicine·Amit V KheraDaniel J Rader
Feb 10, 2011·Nature Reviews. Cardiology·Mohamad NavabAlan M Fogelman

Citations

Aug 8, 2014·Journal of Neuropathology and Experimental Neurology·Eliisa OllikainenPetri T Kovanen
Mar 20, 2015·Thrombosis and Haemostasis·Elena BurilloJose Luis Martin-Ventura
Aug 12, 2015·Nature Reviews. Cardiology·Guo-Ping ShiPetri T Kovanen
Nov 27, 2014·Journal of Lipid Research·Katariina OörniPetri T Kovanen
Dec 19, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Su Duy NguyenPetri T Kovanen
Sep 5, 2015·Current Opinion in Lipidology·Miriam Lee-Rueckert, Petri T Kovanen
Sep 16, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Donna Lee M DinnesLeonard Kritharides
Sep 14, 2019·International Journal of Molecular Sciences·Petri T Kovanen

Related Concepts

Alpha-1 Lipoprotein
Atherogenesis
High-Density Lipoprotein, Pre-beta1
Protein Digestion
Atherosclerosis
Cholesterol
Lipids
Lipolysis
High Density Lipoproteins
Macrophage

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

© 2021 Meta ULC. All rights reserved