PMID: 8594881Dec 1, 1995Paper

Extracellular nucleotide receptor inhibits AVP-stimulated water permeability in inner medullary collecting duct

The American Journal of Physiology
B K KishoreM A Knepper

Abstract

The P2u class of nucleotide receptors is linked to mobilization of intracellular Ca2+ in many cell types, including the renal collecting duct cells. In the present studies, we examined the effects of nucleotides (ATP, UTP, and ADP; 10 microM each) on the arginine vasopressin (AVP, 0.1 nM)-stimulated osmotic water permeability (Pf) in in vitro perfused terminal inner medullary collecting ducts (IMCD) of rat. ATP or UTP, when added to the bath, decreased the AVP-stimulated Pf by approximately 40%. These effects were reversible upon withdrawal of the nucleotides. However, addition of ADP to the bath or sham exchange of the bath had no significant effect on the Pf. Furthermore, ATP did not have any significant effect on the Pf stimulated either by a membrane-permeant, nonhydrolyzable adenosine 3',5'-cyclic monophosphate (cAMP) analogue [8-(4-chlorophenylthio)-cAMP, 0.1 mM] o by forskolin (1 microM). In line with these findings, ATP decreased the AVP-stimulated cAMP levels in IMCD suspensions to approximately 68%. In addition, ATP did not exert an inhibitory effect on the AVP-stimulated Pf in the presence of calphostin C (150 nM), an inhibitor of protein kinase C. These results lead us to conclude the following: 1) agonist occupancy...Continue Reading

Citations

Feb 8, 2000·American Journal of Physiology. Renal Physiology·B K KishoreM A Knepper
May 16, 2001·American Journal of Physiology. Renal Physiology·E M Schwiebert, B K Kishore
Nov 6, 2007·American Journal of Physiology. Renal Physiology·Volker Vallon
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Apr 2, 2011·American Journal of Physiology. Renal Physiology·J David HoltzclawSteven C Sansom
Sep 6, 2011·Annual Review of Physiology·Dominique EladariJanos Peti-Peterdi
Oct 11, 2001·American Journal of Physiology. Renal Physiology·L J DaiG A Quamme
Jun 12, 2003·American Journal of Physiology. Renal Physiology·Brett D WelchBellamkonda K Kishore
Dec 4, 2009·American Journal of Physiology. Renal Physiology·Kevin A StraitDonald E Kohan
Oct 25, 2007·Physiological Genomics·Panapat UawithyaMark A Knepper
Apr 13, 2012·American Journal of Physiology. Renal Physiology·Pablo D CabralJeffrey L Garvin
Jun 12, 2009·American Journal of Physiology. Renal Physiology·Elvin OdgaardJens Leipziger
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Aug 23, 2019·Physiological Reviews·Volker VallonBellamkonda K Kishore
Jul 18, 2019·American Journal of Physiology. Renal Physiology·Venkatesh DeshpandeMark A Knepper
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May 13, 2021·American Journal of Physiology. Cell Physiology·Helle Praetorius
Jun 15, 2007·Biochemical and Biophysical Research Communications·Liuzhe LiShen-Ling Xia

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