Extracellular nucleotide regulation and signaling in cardiac fibrosis

Journal of Molecular and Cellular Cardiology
Tatiana NovitskayaRichard J Gumina

Abstract

Following myocardial infarction, purinergic nucleotides and nucleosides are released via non-specific and specific mechanisms in response to cellular activation, stress, or injury. These extracellular nucleotides are potent mediators of physiologic and pathologic responses, contributing to the inflammatory and fibrotic milieu within the injured myocardium. Via autocrine or paracrine signaling, cell-specific effects occur through differentially expressed purinergic receptors of the P2X, P2Y, and P1 families. Nucleotide activation of the ionotropic (ligand-gated) purine receptors (P2X) and several of the metabotropic (G-protein-coupled) purine receptors (P2Y) or adenosine activation of the P1 receptors can have profound effects on inflammatory cell function, fibroblast function, and cardiomyocyte function. Extracellular nucleotidases that hydrolyze released nucleotides regulate the magnitude and duration of purinergic signaling. While there are numerous studies on the role of the purinergic signaling pathway in cardiovascular disease, the extent to which the purinergic signaling pathway modulates cardiac fibrosis is incompletely understood. Here we provide an overview of the current understanding of how the purinergic signaling p...Continue Reading

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Citations

Aug 2, 2016·Biological & Pharmaceutical Bulletin·Shun WatanabeTsuneo Kobayashi
Oct 21, 2016·Life Sciences·Stephen B SmithRichard J Gumina
Jan 7, 2017·Circulation Research·Geoffrey Burnstock
May 23, 2017·Frontiers in Pharmacology·Elizabeth A VecchioLauren T May
Jun 23, 2020·Oxidative Medicine and Cellular Longevity·Junteng ZhouXiaojing Liu
Sep 25, 2019·Journal of Cardiovascular Development and Disease·Jianlin FengLixia Yue
Oct 11, 2017·Frontiers in Pharmacology·Geoffrey Burnstock
Dec 4, 2020·Biological & Pharmaceutical Bulletin·Takayuki MatsumotoTsuneo Kobayashi
Mar 9, 2021·Frontiers in Pharmacology·Geer TianXiaojing Liu
Nov 14, 2020·International Journal of Molecular Sciences·María Ángeles Martínez-CuestaÁngeles Álvarez
May 14, 2021·Purinergic Signalling·M Reyna-JeldesF G Vázquez-Cuevas
May 18, 2021·Frontiers in Pharmacology·Junteng ZhouXin Cao

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