PMID: 2105821Jan 1, 1990Paper

Extracellular oxytocin in the paraventricular nucleus: hyperosmotic stimulation by in vivo microdialysis

Brain Research
T HattoriD K Sundberg

Abstract

The effect of central osmotic stimulation on oxytocin (OT) secretion from the paraventricular nucleus (PVN) was examined using a newly developed in vivo microdialysis technique. A dialysis probe was inserted into the PVN region and microdialysis was performed in conscious animals. Hyperosmotic solutions were delivered via the dialysis probe, and perfusate and blood samples were collected. OT was consistently detected in the PVN dialysate. Hyperosmotic sodium chloride (1 M) produced a significant increase in dialysate and plasma OT, whereas D-mannitol (2 M) had no effect. These results suggest that (1) in vivo microdialysis may provide a useful technique for the evaluation of neuropeptide secretion from specific brain regions and (2) there are sodium-sensitive cells in the PVN region which respond to increases in extracellular sodium, resulting in an increase in central and peripheral oxytocin secretion.

References

Feb 3, 1978·Brain Research·M J McKinleyR S Weisinger
Jun 1, 1989·Journal of Neurochemistry·H Benveniste
Sep 1, 1986·Acta Physiologica Scandinavica·U Tossman, U Ungerstedt

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Citations

Apr 21, 2006·Cellular and Molecular Neurobiology·Z BacováV Strbák
Jan 1, 1996·Neuroscience and Biobehavioral Reviews·M EngelmannR Landgraf
Apr 1, 1994·Journal of Neuroscience Methods·H TakahashiS Saito
Jan 1, 1994·Brain Research Bulletin·J Y Summy-LongM Kadekaro
Apr 21, 1999·Brain Research Bulletin·M D Madeira, M M Paula-Barbosa
Apr 1, 1995·The European Journal of Neuroscience·R LandgrafQ J Pittman
Apr 24, 1997·Annals of the New York Academy of Sciences·J D CaldwellG A Mason
Feb 17, 2000·Annals of the New York Academy of Sciences·S L Bealer, W R Crowley
Feb 11, 2004·Experimental Neurology·Steven L Bealer, Francis W Flynn
Mar 1, 1993·American Journal of Obstetrics and Gynecology·T KawarabayashiH Sugimori
Dec 20, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Vladimír Strbák
Apr 8, 1998·The American Journal of Physiology·S L Bealer, W R Crowley
Dec 31, 1998·Journal of Neuroendocrinology·M Ludwig
Sep 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Q H JinH Kannan

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