Extracellular pH defense against lactic acid in untrained and trained altitude residents

European Journal of Applied Physiology
Dieter BöningMaría Mercedes Mora

Abstract

The assumption that buffering at altitude is deteriorated by bicarbonate (bi) reduction was investigated. Extracellular pH defense against lactic acidosis was estimated from changes (Delta) in lactic acid ([La]), [HCO3-], pH and PCO2 in plasma, which equilibrates with interstitial fluid. These quantities were measured in earlobe blood during and after incremental bicycle exercise in 10 untrained (UT) and 11 endurance-trained (TR) highlanders (2,600 m). During exercise the capacity of non-bicarbonate buffers (betanbi=-Delta[La]. DeltapH(-1)-Delta[HCO3-]. DeltapH(-1)) amounted to 40+/-2 (SEM) and 28+/-2 mmol l(-1) in UT and TR, respectively (P<0.01). During recovery beta (nbi) decreased to 20 (UT) and 16 (TR) mmol l(-1) (P<0.001) corresponding to values expected from hemoglobin, dissolved protein and phosphate concentrations related to extracellular fluid (ecf). This was accompanied by a larger decrease of base excess after than during exercise for a given Delta[La]. betabi amounted to 37-41 mmol l(-1) being lower than at sea level. The large exercise betanbi was mainly caused by increasing concentrations of buffers due to temporary shrinking of ecf. Tr has lower betanbi in spite of an increased Hb mass mainly because of an expan...Continue Reading

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Citations

Jun 12, 2014·PloS One·Dieter BöningDoris Staab
Jun 13, 2009·High Altitude Medicine & Biology·Stéphane Perrey, Thomas Rupp
Sep 9, 2008·Scandinavian Journal of Medicine & Science in Sports·P Bärtsch, B Saltin
May 22, 2013·Respiratory Physiology & Neurobiology·Dieter Böning, Axel R Pries
Jan 19, 2018·Exercise and Sport Sciences Reviews·Jacob Bejder, Nikolai Baastrup Nordsborg
Feb 17, 2018·European Journal of Applied Physiology·Dieter Böning, Norbert Maassen
Aug 11, 2011·Journal of Applied Physiology·Dieter Böning

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