Extracellular pH is a biomarker enabling detection of breast cancer and liver cancer using CEST MRI

Oncotarget
Miaomiao ChenRenhua Wu

Abstract

Extracellular pH (pHe) decrease is associated with tumor growth, invasion, metastasis, and chemoresistance, which can be detected by chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI). Here, we demonstrated that ioversol CEST MRI can be exploited to achieve pHe mapping of the liver cancer microenvironment. In in vitro studies, we firstly explored whether ioversol signal is pH-dependent, and calculated the function equation between the CEST effects of ioversol and pH values, in the range of 6.0 to 7.8, by a ratiometric method. Then we verified the feasibility of this technique and the equation in vivo by applying pHe imaging in an MMTV-Erbb2 transgenic mouse breast cancer model, which is often used in CEST pHe studies. Furthermore, in vivo ioversol CEST MRI, we were able to map relative pHe and differentiate between tumor and normal tissue in a McA-RH7777 rat hepatoma model. This suggests pHe may be a useful biomarker for human liver cancer.

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Citations

Jan 28, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Joshua M GoldenbergMark D Pagel
Aug 11, 2020·Biomaterials Science·David B BerrySamuel R Ward
Jul 6, 2018·Cancer Immunology, Immunotherapy : CII·Ruben LacroixChristian U Blank
Jul 1, 2020·Cancers·Sabina SanegreTomás Álvaro Naranjo
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Dec 16, 2020·Scientific Reports·Ana Carolina Lima RalphVanessa Morais Freitas
Jan 27, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Feriel RomdhaneDario Livio Longo
Feb 26, 2021·Proceedings of the National Academy of Sciences of the United States of America·Hwai Wen ChangJay M Short
May 8, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Udom M AkpanWinston O Soboyejo
Apr 18, 2021·Medical Physics·Kiaran P McGeeCaroline Chung
Jul 10, 2021·The Journal of Chemical Physics·Megan J ThompsonTina Düren
Apr 21, 2020·ACS Omega·Alicja Trebinska-StryjewskaRenata Bilewicz
Aug 22, 2021·Journal of Pharmaceutical Sciences·Fatemeh GheybiMahmoud Reza Jaafari
Dec 3, 2021·ACS Sensors·Chathuri J KombalaMark D Pagel

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Methods Mentioned

BETA
chemical exchange saturation transfer
X-ray
transgenic
xenograft

Software Mentioned

MATLAB

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