Extracellular phospholipase A2 activity in cell free peritoneal lavage fluid from mice with zymosan peritonitis

Agents and Actions
K R GansJ S Kerr

Abstract

The kinetics and appearance of extracellular phospholipase A2 (PLA2) activity and its relationship to the appearance of arachidonic acid (AA) metabolites in the peritoneal cavity of mice injected with zymosan is described. AA metabolites levels including leukotriene C4 (LTC4) were maximum 15-30 min after zymosan. Peak PLA2 activity was also found 15-30 min after zymosan and was significantly increased above levels found in saline control exudates (3.83 +/- 0.89 and 0.35 +/- 0.11, respectively, p less than or equal to 0.05). Results show that an extracellular PLA2 is present in zymosan peritonitis.

References

Apr 18, 1972·Biochimica Et Biophysica Acta·P PatriarcaP Elsbach
Sep 15, 1982·Biochemical Pharmacology·K OhuchiS Tsurufuji

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Citations

Sep 1, 1991·Agents and Actions·L R MarinariB M Weichman
Aug 4, 1999·Critical Reviews in Clinical Laboratory Sciences·E Kaiser
May 26, 2012·Pharmacology & Therapeutics·M J Paul-ClarkJ A Mitchell
Feb 7, 2008·Annals of Botany·Veronica de MiccoKatia Ruel

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