Extracellular potassium accumulation in the frog spinal cord induced by stimulation of the skin and ventrolateral columns

The Journal of Physiology
G CzéhE Syková

Abstract

1. Changes in extracellular K(+) concentration (Delta[K](e)), dorsal root potentials (DRPs) and single unit activity were studied in the frog spinal cord in response to stimulation of the skin of the hindlimb by touch, pressure, hot water (heat), single electrical pulses and to stimulation of the ventrolateral columns (LC).2. Single electrical pulses, various types of adequate stimulation applied to the skin of the hind limb for 1-2 s as well as single volleys of LC led to a Delta[K](e) of up to 0.2 mmol.l(-1). Stimuli which evoked larger Delta[K](e) also produced larger DRPs in the same frog preparation.3. The briefest heat stimuli, which lasted about 1-2 s, led to more prolonged activity in dorsal horn interneurones than did a single volley or a single tactile stimulus and the Delta[K](e) were longer and larger and had a slower rise time.4. The ;slow' second component of dorsal root depolarization (presumably mediated by K(+)) was observed after electrical and heat stimulation of the skin on the hind limb corresponding to the time course of Delta[K](e).5. The maximum Delta[K](e) induced by nociceptive stimulation occurred in the grey matter of the dorsal horn at a depth of 300-600 mum from the dorsal surface. The maximum resp...Continue Reading

Citations

Jan 1, 1983·Progress in Biophysics and Molecular Biology·E Syková
Oct 1, 1993·Pain·Hans-Georg Schaible, Blair D Grubb
Jan 1, 1988·Annals of the New York Academy of Sciences·P Johnson
Oct 2, 2015·American Journal of Physiology. Renal Physiology·Nicolas MontalbettiMarcelo D Carattino
Apr 4, 2019·Scientific Reports·Nicolas MontalbettiMarcelo D Carattino
Jul 1, 1988·Pflügers Archiv : European journal of physiology·E SykováN Kríz

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