Extracellular potentials modify the transfer of information at photoreceptor output synapses in the blowfly compound eye.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Matti Weckström, S B Laughlin

Abstract

Signal processing in fly photoreceptors and visual interneurons takes place with graded potentials. Photoreceptors drive large monopolar cells (LMCs) with synapses that, like their counterparts in vertebrates, have a high gain and introduce strong spatiotemporal antagonism (Laughlin et al., 1987) that implements predictive coding (Srinivasan et al., 1982). The synapses are contained in compartments, lamina cartridges, whose extracellular potentials change with illumination (Shaw, 1984). We described these extracellular field potentials (FPs) using a novel permeabilization technique that converts neurons into extracellular recording probes. Having characterized extracellular FPs, we went on to study them using conventional microelectrodes. Extracellular space in a cartridge is electrically isolated from the body cavity and retina [input resistance (R(in)) = 6.0 MOmega in dark], and light adaptation increases this isolation (R(in) = 7.8 MOmega). In the dark, the extracellular space is 30 mV hyperpolarized compared with retina, and this promotes tonic synaptic activity by depolarizing the synaptic terminals. Illumination depolarizes the extracellular space, and voltage-clamp studies suggest that the postsynaptic chloride current i...Continue Reading

Citations

Nov 25, 2011·Journal of Neurophysiology·Peter W Jones, Fabrizio Gabbiani
Dec 21, 2012·American Journal of Preventive Medicine·Pooja S TandonDimitri A Christakis
Nov 28, 2012·Journal of Physiology, Paris·Anne-Kathrin WarzechaJan Grewe
May 15, 2012·Progress in Retinal and Eye Research·Wallace B Thoreson, Stuart C Mangel
Apr 7, 2017·Scientific Reports·Elisa RigosiDavid C O'Carroll
Sep 19, 2018·The Journal of Experimental Biology·Paulus SaariRoman V Frolov
Dec 12, 2019·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Burak GürMarion Silies
Feb 27, 2021·Current Biology : CB·Manuel PagniChristopher Schnaitmann

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