Extracellular proteins organize the mechanosensory channel complex in C. elegans touch receptor neurons

Neuron
Lesley EmtageMartin Chalfie

Abstract

Specialized extracellular matrix (ECM) is associated with virtually every mechanosensory system studied. C. elegans touch receptor neurons have specialized ECM and attach to the surrounding epidermis. The mec-1 gene encodes an ECM protein with multiple EGF and Kunitz domains. MEC-1 is needed for the accumulation of the collagen MEC-5 and other ECM components, attachment, and, separately, for touch sensitivity. MEC-1 and MEC-5 bind to touch processes uniformly and in puncta. These puncta colocalize with and localize the mechanosensory channel complex in the touch neurons. In turn, the production of the MEC-1 and MEC-5 puncta appears to rely on interactions with the neighboring epidermal tissue. These and other observations lead us to propose that extracellular, but not cytoskeletal, tethering of the degenerin channel is needed for mechanosensory transduction. Additionally, our experiments demonstrate an important role of the ECM in organizing the placement of the channel complex.

References

Jun 1, 1979·Biophysical Journal·David P Corey, A J Hudspeth
Jul 1, 1979·The Journal of Cell Biology·Martin Chalfie, J N Thomson
Aug 1, 1991·The Journal of Cell Biology·R Francis, Robert H Waterston
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Mar 1, 1981·Developmental Biology·Martin Chalfie, J Sulston
May 1, 1995·The Journal of Cell Biology·S N GettnerL F Reichardt
Oct 1, 1993·Genes & Development·R Pulak, P Anderson
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·Guoqiang GuMartin Chalfie
Apr 17, 1997·Nature·M R KaplanB A Barres
Aug 12, 1999·The Journal of Cell Biology·M C HreskoRobert H Waterston
Apr 1, 2000·Science·R G WalkerC S Zuker
May 17, 2002·Current Biology : CB·A Craig MackinnonBenjamin D Williams
Nov 14, 2002·Annual Review of Genetics·Glen G Ernstrom, Martin Chalfie
Nov 19, 2003·PLoS Biology·Lincoln D SteinRobert H Waterston
Apr 2, 2004·Nature·Jan SiemensUlrich Müller
Apr 2, 2004·Nature·Christian SöllnerTübingen 2000 Screen Consortium

Citations

Nov 18, 2008·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Stephan Frings
Feb 8, 2007·Pflügers Archiv : European journal of physiology·Alexander Bounoutas, Martin Chalfie
Sep 18, 2007·Pflügers Archiv : European journal of physiology·Martin Fronius, Wolfgang G Clauss
Aug 2, 2008·Cell Death and Differentiation·W ZhangMonica Driscoll
Jun 1, 2010·Nature Methods·Andrea CalixtoMartin Chalfie
Feb 7, 2009·Nature Reviews. Molecular Cell Biology·Martin Chalfie
Oct 13, 2006·Cell Research·Bruce E VogelXuehong Xu
May 17, 2011·Proceedings of the National Academy of Sciences of the United States of America·Chun-Liang PanSteven McIntire
Nov 17, 2011·Proceedings of the National Academy of Sciences of the United States of America·Irini Topalidou, Martin Chalfie
Mar 3, 2010·Annual Review of Biophysics·Jóhanna Arnadóttir, Martin Chalfie
Oct 1, 2010·Journal of Neurophysiology·Marios ChatzigeorgiouWilliam R Schafer
Apr 11, 2008·BMC Developmental Biology·Claes AxängMarc Pilon
Dec 1, 2007·WormBook : the Online Review of C. Elegans Biology·M B Goodman
Sep 13, 2007·Proceedings of the National Academy of Sciences of the United States of America·Zilu WuAndrew D Chisholm
Aug 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Todd LamitinaKevin Strange
Oct 3, 2012·Physiology·Amy L Eastwood, M B Goodman
Feb 16, 2016·Cell Reports·Annika L A NicholsMassimo A Hilliard
Oct 20, 2010·The Journal of Cell Biology·Ellen A LumpkinAislyn M Nelson
Dec 3, 2015·Proceedings of the National Academy of Sciences of the United States of America·Amy L EastwoodM B Goodman
Oct 17, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Limor BrodayZe'ev Ronai
Jun 29, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Joaquin M MurielBruce E Vogel
Mar 30, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Andrew D Chisholm, Suhong Xu
Jan 16, 2010·The EMBO Journal·Jing HuGary R Lewin
Jan 20, 2015·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Michael KriegM B Goodman
Jul 19, 2005·Current Opinion in Neurobiology·Ellen A Lumpkin, Diana M Bautista
Nov 14, 2015·Annual Review of Cell and Developmental Biology·Samata KattaM B Goodman
Jul 21, 2009·Current Biology : CB·Alexander BounoutasMartin Chalfie
Jan 1, 2007·Current Topics in Membranes·Dafne Bazopoulou, Nektarios Tavernarakis
Feb 24, 2006·International Review of Neurobiology·David H HallZeynep Altun
Feb 14, 2008·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·John GardinerRobyn Overall
Oct 26, 2018·ELife·Chun-Chun ChengHironobu Fujiwara
Jun 23, 2007·Nature Reviews. Neuroscience·Adam P Christensen, David P Corey
Jul 20, 2006·American Journal of Physiology. Renal Physiology·Lisa M SatlinThomas R Kleyman
Jul 18, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Samira C GrifoniHeather A Drummond
Apr 27, 2007·American Journal of Physiology. Renal Physiology·Marcelo D CarattinoThomas R Kleyman
Jan 10, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Ursula StorchThomas Gudermann
Jun 5, 2016·The EMBO Journal·Kishore K JoshiChristopher Rongo
Sep 20, 2019·The Journal of General Physiology·Samata KattaM B Goodman
Feb 22, 2020·Annual Review of Neuroscience·Peng JinYuh-Nung Jan
Oct 28, 2019·The Journal of General Physiology·Katherine M Perks, Jonathan T Pierce
Apr 5, 2013·American Journal of Physiology. Renal Physiology·Wen-Shuo ChungHeather A Drummond
Jul 22, 2018·Integrative Biology : Quantitative Biosciences From Nano to Macro·E A MazzochetteB L Pruitt
Dec 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Fenja KnoeppMartin Fronius

Related Concepts

MEC-5 protein, C elegans
Mec-4 protein, C elegans
Alleles
Zyderm
Epidermal Growth Factor
Meissner's Corpuscle
Cell Surface Proteins
Drug or Chemical Tissue Distribution
Touch Sensation
Extracellular Matrix Proteins

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.