Extracellular recording of localized electrical activity in denervated frog slow muscle fibres

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
J Lehouelleur, H Schmidt

Abstract

Pyriformis muscles of Rana temporaria were denervated by cutting the sciatic nerve in the pelvis. Slow muscle fibres were depolarized with intracellular current pulses, and the electrical activity was recorded simultaneously with intracellular and extracellular recording electrodes. When the extracellular electrode was moved along the fibre surface, outward and inward currents of variable amplitude were recorded. Inward currents coincided with the fast rising phase of the intracellularly recorded action potential; up to four inward current peaks could be detected in single fibres investigated over 3.4--8 mm of their length. The distance between inward current peaks was generally 1--2 mm, but greater distances were also observed. Composite action potentials could be shown to be due to inward currents arising in separate areas of the slow fibre membrane. It is concluded that after denervation Na-channels are incorporated into spatially limited areas of the membrane of slow muscle fibres.

References

Jan 15, 1979·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·G Schalow, H Schmidt
Nov 25, 1977·Pflügers Archiv : European journal of physiology·G Schalow, H Schmidt
Feb 1, 1974·Acta Physiologica Scandinavica·G A Nasledov, S Thesleff
Aug 1, 1965·The Journal of Cell Biology·S G Page
Jun 28, 1956·The Journal of Physiology·W BURKE, B L GINSBORG
Feb 16, 1965·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·B KATZ, R MILEDI

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Citations

Sep 1, 1984·Pflügers Archiv : European journal of physiology·J LehouelleurH Schmidt
Jan 1, 1985·Progress in Biophysics and Molecular Biology·J CailléO Rougier

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