Extracellular RNAs: development as biomarkers of human disease

Journal of Extracellular Vesicles
Joseph F QuinnJulie A Saugstad

Abstract

Ten ongoing studies designed to test the possibility that extracellular RNAs may serve as biomarkers in human disease are described. These studies, funded by the NIH Common Fund Extracellular RNA Communication Program, examine diverse extracellular body fluids, including plasma, serum, urine and cerebrospinal fluid. The disorders studied include hepatic and gastric cancer, cardiovascular disease, chronic kidney disease, neurodegenerative disease, brain tumours, intracranial haemorrhage, multiple sclerosis and placental disorders. Progress to date and the plans for future studies are outlined.

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Citations

Mar 22, 2016·Nature Reviews. Genetics·Sara A ByronDavid W Craig
Oct 30, 2016·Expert Review of Molecular Diagnostics·Tania B LomboDanilo A Tagle
Nov 5, 2016·Journal of Alzheimer's Disease : JAD·Theresa A LusardiJulie A Saugstad
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Nov 20, 2016·Journal of Extracellular Vesicles·Reka A HarasztiAnastasia Khvorova
Oct 1, 2020·HNO·M WalleschB Wollenberg
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Jul 19, 2017·Journal of Extracellular Vesicles·Julie A SaugstadFred H Hochberg
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Methods Mentioned

BETA
PCR
RNA-Seq
prophylactic therapy
biopsy
reverse transcription PCR

Software Mentioned

NanoString
exRNA

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