PMID: 9440506Jan 24, 1998Paper

Extracellular signal molecule(s) involved in the carbon starvation response of marine Vibrio sp. strain S14

Journal of Bacteriology
S SrinivasanS Kjelleberg

Abstract

The role of exogenous metabolites as putative signal molecules mediating and/or regulating the carbon starvation adaptation program in Vibrio sp. strain S14 was investigated. Addition of the stationary-phase supernatant extract (SSE) of Vibrio sp. strain S14 to logarithmic-phase cells resulted in a significant number of carbon starvation-induced proteins being up-regulated. Halogenated furanones, putative antagonists of acylated homoserine lactones (AHLs), inhibited the synthesis of proteins specifically induced upon carbon starvation. The effect of the furanone was the opposite of that caused by SSE with respect to the up- and down-regulation of protein expression, indicating that both the furanone and the putative signalling molecules were acting on the same regulatory pathway. Culturability was rapidly lost when Vibrio sp. strain S14 was starved in the presence of the furanone at a low concentration. The furanone also had a negative effect on the ability of carbon-starved cells to mount resistance against UV irradiation and hydrogen peroxide exposure. The SSE of Vibrio sp. strain S14 had the ability to provide cross-protection against the loss in viability caused by the furanone. We have further demonstrated that the SSE tak...Continue Reading

References

Jan 1, 1992·Annual Review of Microbiology·S Horinouchi, T Beppu
Dec 1, 1995·Journal of Bacteriology·J OstlingS Kjelleberg
Nov 1, 1993·Journal of Bacteriology·Y ShigaH Akanuma
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Jun 1, 1996·Trends in Microbiology·A S Kaprelyants, D B Kell
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Jan 1, 1990·Applied and Environmental Microbiology·N H AlbertsonS Kjelleberg

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Citations

Aug 6, 2005·Analytical and Bioanalytical Chemistry·Peter J SchuppPeter D Steinberg
Jul 12, 2003·Microbiology·Diane McDougaldStaffan Kjelleberg
Sep 24, 2004·Infection and Immunity·David L EricksonDouglas G Storey
Sep 12, 2012·Journal of Molecular Microbiology and Biotechnology·Neelam MangwaniSurajit Das
Jan 3, 2001·Journal of Bacteriology·D McDougaldS Kjelleberg
Dec 14, 2005·Environmental Microbiology·Denise DagninoJoão Carlos de Aquino Almeida
Oct 3, 2007·FEMS Microbiology Ecology·Inés AranaIsabel Barcina
Jul 9, 2004·Applied and Environmental Microbiology·Michael W TaylorPeter D Steinberg
Jan 1, 2014·Molecular Microbiology·Xiaobo KeBonnie L Bassler
Apr 4, 2000·Current Opinion in Microbiology·B A Lazazzera
Apr 28, 2001·Journal of Natural Products·R de NysS Kjelleberg

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