Extracellular signal-regulated kinase 1 and 2 in cancer therapy: a focus on hepatocellular carcinoma

Molecular Biology Reports
Amir MehdizadehMortaza Jabbarpour-Bonyadi

Abstract

Extracellular signal-regulated kinases (ERK) pathway plays a crucial role in cancer cell survival and proliferation. This signaling pathway has been related to epithelial to mesenchymal transition and drug resistance in hepatocellular carcinoma (HCC) cells, which is a common challenge in chemotherapy. Consequently, mediators of this pathway have recently been considered as novel therapeutic targets in HCC. In this review the impact of ERK1 and ERK2 as major components of ERK signaling pathway, in HCC biology and drug resistance will be highlighted and discussed.

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Citations

Oct 27, 2018·Journal of Cellular Physiology·Khalil HajiasgharzadehBehzad Baradaran
Jun 16, 2019·International Journal of Molecular Sciences·Monserrat Olea-FloresNapoleón Navarro-Tito
Oct 19, 2016·Journal of Hepatology·Jian ShenJianping Zhang
Mar 26, 2019·Journal of Chemical Information and Modeling·Laurent HofferPhilippe Roche

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