PMID: 26767647DOI: 10.1007/s11033-016-3943-9Jan 16, 2016Paper
Extracellular signal-regulated kinase 1 and 2 in cancer therapy: a focus on hepatocellular carcinoma
Molecular Biology Reports
Amir MehdizadehMortaza Jabbarpour-Bonyadi
Abstract
Extracellular signal-regulated kinases (ERK) pathway plays a crucial role in cancer cell survival and proliferation. This signaling pathway has been related to epithelial to mesenchymal transition and drug resistance in hepatocellular carcinoma (HCC) cells, which is a common challenge in chemotherapy. Consequently, mediators of this pathway have recently been considered as novel therapeutic targets in HCC. In this review the impact of ERK1 and ERK2 as major components of ERK signaling pathway, in HCC biology and drug resistance will be highlighted and discussed.
References
Mar 1, 1992·Journal of Hepatology·C ChallenM F Bassendine
Jul 9, 1997·Biochemical and Biophysical Research Communications·C M SchmidtJ V Sitzmann
Dec 16, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I H McKillopJ V Sitzmann
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y ItoM Hori
Feb 16, 1999·Oncogene·R HoshinoM Kohno
Mar 29, 2002·International Journal of Cancer. Journal International Du Cancer·Jason A Bush, Gang Li
May 23, 2002·Gastroenterology·Alex S Befeler, Adrian M Di Bisceglie
Apr 15, 2003·Gut·A TannapfelC Wittekind
Jun 5, 2003·Nature Reviews. Cancer·Marcos Malumbres, Mariano Barbacid
Jul 2, 2003·Leukemia·F ChangJ A McCubrey
Apr 1, 1963·Journal of Molecular Biology·J MONODF JACOB
Oct 7, 2004·Cancer Research·Scott M WilhelmPamela A Trail
Nov 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Charles M RudinMark J Ratain
Jul 8, 2005·Journal of Medicinal Chemistry·Chad N HancockPaul Shapiro
Sep 6, 2005·Biochemical and Biophysical Research Communications·Makoto OhoriTakashi Fujii
Nov 17, 2005·Oncogene·Lionel Larue, Alfonso Bellacosa
Feb 21, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anatoly DritschiloUsha N Kasid
Mar 15, 2006·Neoplasia : an International Journal for Oncology Research·Patrick J KleinJudith S Sebolt-Leopold
May 25, 2006·Annals of Medicine·Michiaki Kohno, Jacques Pouyssegur
Jun 30, 2006·Journal of Biology·Chiara VantaggiatoRiccardo Brambilla
Aug 16, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ghassan K Abou-AlfaLeonard B Saltz
Nov 24, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Makoto OhoriHiroshi Miyake
Nov 28, 2006·Biochimica Et Biophysica Acta·James A McCubreyRichard A Franklin
Dec 13, 2006·Cancer Chemotherapy and Pharmacology·Yong S ChangScott Wilhelm
Dec 21, 2006·Cancer Research·Li LiuChristopher Carter
Dec 30, 2006·Biochemical and Biophysical Research Communications·Makoto OhoriHiroshi Miyake
Dec 30, 2006·Biochimica Et Biophysica Acta·Ding WangPatricia M LoRusso
Mar 14, 2007·The American Journal of Medicine·Sameer Parikh, David Hyman
May 15, 2007·Oncogene·P J Roberts, C J Der
Nov 14, 2007·Journal of Hepatology·Klaus Juergen SchmitzHideo Andreas Baba
May 13, 2008·The Journal of Surgical Research·Jennifer ChoiC Max Schmidt
Jun 4, 2008·Oncogene·A BessardG Baffet
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Dec 24, 2008·Nature Reviews. Cancer·Jianming ZhangNathanael S Gray
Mar 5, 2009·The Journal of Pharmacology and Experimental Therapeutics·Michele T Yip-SchneiderC Max Schmidt
Mar 27, 2009·World Journal of Gastroenterology : WJG·Feng YanQuan-Ming Ma
Apr 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Sudipta BasuShiladitya Sengupta
Aug 25, 2009·BMC Medicine·Zhe ZhangYanhong Wang
Oct 27, 2009·Future Oncology·Franziska van ZijlWolfgang Mikulits
Dec 17, 2009·Journal of Medicinal Chemistry·Fabio ZuccottoMauro Angiolini
Apr 14, 2010·Molecular Cell·Sejeong ShinJohn Blenis
Jan 25, 2011·Pharmacology & Therapeutics·Richard Eglen, Terry Reisine
Apr 2, 2011·Nature Reviews. Drug Discovery·Juswinder SinghAdrian Whitty
Apr 22, 2011·Molecular Cancer·Mingmei LiaoXingming Deng
May 10, 2011·Annual Review of Biochemistry·Arvin C Dar, Kevan M Shokat
Jul 23, 2011·Genes & Cancer·Inbal Wortzel, Rony Seger
Jan 20, 2012·Cell Death & Disease·M ColombinoG Palmieri
Feb 10, 2012·American Journal of Medical Genetics. Part a·Jeroen BreckpotKoenraad Devriendt
Mar 20, 2012·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver, UNKNOWN European Organisation For Research And Treatment Of Cancer
May 10, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Robert Roskoski
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Citations
May 30, 2019·Journal of Chemotherapy·Cumali DegirmenciAyşe Yagcı
Sep 13, 2018·Anti-cancer Agents in Medicinal Chemistry·Nimmy KumarRichard Lobo
Oct 27, 2018·Journal of Cellular Physiology·Khalil HajiasgharzadehBehzad Baradaran
Dec 28, 2018·Carcinogenesis·Fabia de Oliveira AndradeFernando Salvador Moreno
Jan 7, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Amir MehdizadehMortaza Bonyadi
Jan 21, 2018·Molecular Oncology·Kanika SharmaHisashi Harada
Jul 7, 2018·Therapeutic Advances in Endocrinology and Metabolism·Samira KahnamouyiAmir Mehdizadeh
Aug 26, 2018·Fundamental & Clinical Pharmacology·Alecsander F BressanFernanda Regina Giachini
Jul 17, 2019·Journal of Cellular Physiology·Mei DuAihua Wang
Jun 16, 2019·International Journal of Molecular Sciences·Monserrat Olea-FloresNapoleón Navarro-Tito
Dec 24, 2018·Cancers·Ren-In YouChi-Tan Hu
Oct 19, 2016·Journal of Hepatology·Jian ShenJianping Zhang
Aug 9, 2021·Translational Oncology·Aniketh BishnuPritha Ray
Mar 26, 2019·Journal of Chemical Information and Modeling·Laurent HofferPhilippe Roche
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