Extracellular Signal-Regulated Kinase 1/2 Regulates Mouse Kidney Injury Molecule-1 Expression Physiologically and Following Ischemic and Septic Renal Injury

The Journal of Pharmacology and Experimental Therapeutics
Justin B Collier, Rick G Schnellmann

Abstract

The upregulation of kidney injury molecule-1 (KIM-1) has been extensively studied in various renal diseases and following acute injury; however, the initial mechanisms controlling KIM-1 expression remain limited. In this study, KIM-1 expression was examined in mouse renal cell cultures and in two different models of acute kidney injury (AKI), ischemia reperfusion (IR)-induced and lipopolysaccharide (LPS)-induced sepsis. KIM-1 mRNA increased in both AKI models, and pharmacological inhibition of extracellular signal-regulated kinase 1/2 (ERK1/2) signaling attenuated injury-induced KIM-1 expression in the renal cortex. Toll-like receptor 4 knockout (TLR4KO) mice exhibited reduced ERK1/2 phosphorylation and attenuated KIM-1 mRNA after LPS exposure. TLR4KO mice were not protected from IR-induced ERK1/2 phosphorylation and upregulation of KIM-1 mRNA. Following renal IR injury, phosphorylation of signal transducer and activator of transcription 3 (STAT3) at serine 727 and tyrosine 705 increased downstream from ERK1/2 activation. Because phosphorylated STAT3 is a transcriptional upregulator of KIM-1 and inhibition of ERK1/2 attenuated increases in STAT3 phosphorylation, we suggest an ERK1/2-STAT3-KIM-1 pathway following renal injury. F...Continue Reading

References

Mar 1, 1988·Kidney International·K MacKayG E Striker
Aug 1, 1995·The American Journal of Physiology·S Ernest, E Bello-Reuss
Jul 26, 2002·The Journal of Biological Chemistry·Veronique BaillyJoseph V Bonventre
Mar 13, 2003·Kidney International·Takao MasakiDavid J Nikolic-Paterson
Mar 23, 2004·Environmental Health Perspectives·Rupesh P AminCynthia A Afshari
May 20, 2004·American Journal of Physiology. Renal Physiology·Istvan AranyRobert L Safirstein
Jun 24, 2004·Journal of the American Society of Nephrology : JASN·Takao MasakiDavid J Nikolic-Paterson
Mar 4, 2005·Journal of the American Society of Nephrology : JASN·Won K HanJoseph V Bonventre
Sep 22, 2005·American Journal of Physiology. Renal Physiology·Vishal S VaidyaJoseph V Bonventre
Feb 10, 2006·American Journal of Physiology. Renal Physiology·Mirjan M van TimmerenHarry van Goor
May 18, 2006·American Journal of Physiology. Renal Physiology·Grazyna NowakDiana Bakajsova
Sep 28, 2007·Journal of the American Society of Nephrology : JASN·Zhiwei ZhangJoseph V Bonventre
Mar 14, 2008·Journal of the American Society of Nephrology : JASN·Yael Nechemia-ArbelyJonathan H Axelrod
Apr 17, 2008·The Journal of Clinical Investigation·Takaharu IchimuraJoseph V Bonventre
May 13, 2008·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Takaharu Ichimura, Shan Mou
Jan 30, 2009·Bioinformatics·Alexander Lachmann, Avi Ma'ayan
Sep 1, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Justin D EllettKenneth D Chavin
Nov 7, 2009·Journal of the American Society of Nephrology : JASN·Li ZhouHui Y Lan
Jan 20, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Aidan G GilmartinSylvie G Laquerre
Apr 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey J TalbotThomas Weimbs
Aug 9, 2011·Human Molecular Genetics·Ayumi TakakuraJing Zhou
Dec 14, 2011·American Journal of Physiology. Renal Physiology·Jason A Funk, Rick G Schnellmann
May 16, 2014·American Journal of Physiology. Renal Physiology·Rushi GandhiLakshman Gunaratnam
Jun 7, 2014·Journal of the American Society of Nephrology : JASN·Venkata S SabbisettiJoseph V Bonventre
Nov 22, 2014·Current Opinion in Nephrology and Hypertension·Frank C Brosius, John Cijiang He
Apr 17, 2016·Molecular and Cellular Biochemistry·Zhiwei Zhang, Cindy X Cai
Nov 22, 2016·Genes·Amanpreet Singh, Yong-Jie Xu
Feb 20, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Lei TianZhaohui Ni

❮ Previous
Next ❯

Citations

Dec 12, 2018·Journal of the American Society of Nephrology : JASN·Petros AndrikopoulosMuhammad M Yaqoob
Feb 3, 2019·The Journal of Pharmacology and Experimental Therapeutics·Robert B CameronRick G Schnellmann
Oct 9, 2019·Antimicrobial Agents and Chemotherapy·Sophia L SamodelovGerd A Kullak-Ublick
Dec 25, 2019·Cellular and Molecular Life Sciences : CMLS·Justin B Collier, Rick G Schnellmann
Sep 28, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chen YangHua-Feng Liu
Jun 22, 2021·American Journal of Physiology. Renal Physiology·Mohammad M Al-BatainehRebecca P Hughey
Aug 6, 2021·Journal of Biochemical and Molecular Toxicology·Carolina Ruiz-RamirezMinerva Martinez-Alfaro

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.