Extracellular signal-regulated kinases are involved in the acute activation of steroidogenesis in immature rat Leydig cells by human chorionic gonadotropin

Endocrinology
N MartinelleK Svechnikov

Abstract

We studied the involvement of the ERK cascade in human chorionic gonadotropin (hCG)-induced steroidogenesis by primary cultures of immature rat Leydig cells. Our findings indicate that protein kinase A and protein kinase C function as upstream kinases in connection with transduction of the signal from the gonadotropin receptor to the ERK cascade. These MAPKs enhance the stimulatory effects of hCG on the de novo synthesis of the steroidogenic acute regulatory protein and the activity of protein phosphatase 2A, which are associated with increased androgen production by the Leydig cell. Specific inhibition of ERK1/2 by Uo126 suppressed all of these cellular responses to hCG. In contrast, steroidogenesis from 22OHC (a cell-permeable form of cholesterol) is not inhibited by Uo126, suggesting that cholesterol delivery to mitochondria is being affected by this compound. We propose that the ERK cascade is an important part of the signal transduction pathway involved in the rapid hormonal responses of Leydig cells to trophic hormones. In hCG-activated Leydig cells, these MAPKs may play a role in controlling the biosynthesis of the steroidogenic acute regulatory protein as well as regulating protein phosphatase 2A activity, thereby gover...Continue Reading

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Citations

Apr 25, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A W KrugM Ehrhart-Bornstein
Oct 17, 2008·Journal of Toxicology and Environmental Health. Part a·Ju Young RyuHyung Sik Kim
Jul 20, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Heather JohnstonPeter J O'Shaughnessy
Jun 4, 2011·Journal of Signal Transduction·Pulak R Manna, Douglas M Stocco
Aug 3, 2005·FEBS Letters·Yung-Chia ChenSeu-Mei Wang
Dec 11, 2007·The International Journal of Biochemistry & Cell Biology·María Guadalupe Maldonado-MercadoFederico Martinez
Nov 14, 2014·The Prostate·Shigang XiongJacek Pinski
Oct 9, 2015·Yonsei Medical Journal·Young Suk ChoiEun Jig Lee
Oct 21, 2015·Frontiers in Endocrinology·Prema Narayan
Feb 21, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Aleksandra Głodek, Anna Jankowska
Apr 29, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Mélodie DiotJoëlle Dupont
Aug 21, 2015·Asian Journal of Andrology·Ze HeBing Yao
Nov 15, 2008·Molecular and Cellular Endocrinology·Cecilia PoderosoErnesto J Podesta
Feb 14, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Iuliia SavchukKonstantin Svechnikov
Jan 23, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Petra KubincováIva Sovadinová
Mar 22, 2007·American Journal of Physiology. Endocrinology and Metabolism·Guey-Shyang HwangPaulus S Wang

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