Extracellular signals and reversible protein phosphorylation: what to Mek of it all

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Extracellular signals and reversible protein phosphorylation: what to Mek of it all

Abstract

References

Raf-1 activates MAP kinase-kinase.

Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro.

Activation of the MAP kinase pathway by the protein kinase raf.

Both p21ras and pp60v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase

Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product

The mitogen-activated protein kinase activator

Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells.

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

Identification of the SH3 domain of GAP as an essential sequence for Ras-GAP-mediated signaling

Complex formation between RAS and RAF and other protein kinases

Mammalian Ras interacts directly with the serine/threonine kinase Raf

A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf

A short, disordered protein region mediates interactions between the homeodomain of the yeast alpha 2 protein and the MCM1 protein

Agrobacterium conjugation and gene regulation by N-acyl-L-homoserine lactones

Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

Differential antagonism of Ras biological activity by catalytic and Src homology domains of Ras GTPase activation protein

Citations

Signal transduction by basic fibroblast growth factor in rat osteoblastic Py1a cells

Structure and function of the receptor-like protein kinases of higher plants

Heterodimerization and functional interaction between EGF receptor family members: a new signaling paradigm with implications for breast cancer research

Aberrant function of the Ras signal transduction pathway in human breast cancer

Signal transduction mechanisms in the regulation of protein synthesis

Activation of raf-1, MEK, and MAP kinase in prolactin responsive mammary cells

Role of MAP kinase in neurons

Attenuation of glucocorticoid receptor levels by the H-ras oncogene

Tyrosine phosphorylation and stimulation of protein kinase C delta from porcine spleen by src in vitro. Dependence on the activated state of protein kinase C delta

Effects of endothelin on mitogen-activated protein kinase activity and protein synthesis in isolated adult feline cardiac myocytes

Serine/threonine protein phosphatases in the control of cell function

Regulation of BCR- and PKC/Ca(2+)-mediated activation of the Raf1/MEK/MAPK pathway by protein-tyrosine kinase and -tyrosine phosphatase activities

Protein kinases and phosphatases that act on histidine, lysine, or arginine residues in eukaryotic proteins: a possible regulator of the mitogen-activated protein kinase cascade

Stage-specific regulation of protein phosphorylation in Leishmania major

Molecular mechanisms in the control of translation by hormones and growth factors

Cellular components of nerve growth factor signaling

Transient expression of the mitogen-activated protein kinase phosphatase MKP-1 (3CH134/ERP1) in the rat brain after limbic epilepsy

What are the functions of the pertussis toxin-insensitive G proteins G12, G13 and Gz?

Signal transduction by cell adhesion receptors

Influence of neurotrophic factors on morphine- and cocaine-induced biochemical changes in the mesolimbic dopamine system

Regulation of signalling pathways to the nucleus by dopaminergic receptors

Immediate-early genes induced by antigen receptor stimulation

IL-2 signaling: recruitment and activation of multiple protein tyrosine kinases by the components of the IL-2 receptor

Chemosensing and signal transduction in bacteria

Inhibitory effects of androstenedione on endometrial cells: implications for poor reproductive outcome among women with androgen excess

Mitogen-activated protein kinase pathways and cardiac surgery

Potentiation of mitogen-activated protein kinase by ethanol in embryonic liver cells

The Raf-1/mitogen-activated protein kinase kinase-1/extracellular signal-regulated-2 signaling pathway as prerequisite for interleukin-2 gene transcription in lectin-stimulated human primary T lymphocytes

Down-regulation of the dual-specificity phosphatase MKP-1 suppresses tumorigenicity of pancreatic cancer cells

Histological and functional analysis of vascular smooth muscle cells in a novel culture system with honeycomb-like structure

Epidermal growth factor activates extracellular signal-regulated protein kinases (ERK) in freshly isolated porcine granulosa cells

The p21-Ras signal transduction pathway and growth regulation in human high-grade gliomas

Delta opioid receptors expressed by stably transfected jurkat cells signal through the map kinase pathway in a ras-independent manner

The Raf/MEK/ERK pathway: new concepts of activation

Heptachlor and the mitogen-activated protein kinase module in human lymphocytes

The neurotrophic action and signalling of epidermal growth factor

Leptin promotes the tyrosine phosphorylation of SHC proteins and SHC association with GRB2.

Steroid-independent activation of androgen receptor in androgen-independent prostate cancer: a possible role for the MAP kinase signal transduction pathway?

Androgen stimulates mitogen-activated protein kinase in human breast cancer cells

Stimulation by extracellular ATP and UTP of the stress-activated protein kinase cascade in rat renal mesangial cells

Cellular signalling pathways: new targets in leukaemia therapy

Modulation of molecular mechanisms involved in protein synthesis machinery as a new tool for the control of cell proliferation

Mammalian mitogen-activated protein kinase kinase kinase (MEKK) can function in a yeast mitogen-activated protein kinase pathway downstream of protein kinase C

Protein-tyrosine-phosphatase 2C is phosphorylated and inhibited by 44-kDa mitogen-activated protein kinase

Evidence that inactive p42 mitogen-activated protein kinase and inactive Rsk exist as a heterodimer in vivo

A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function

Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases

Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module

Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras

Light and nutritional regulation of transcripts encoding a wheat protein kinase homolog is mediated by cytokinins

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