Extracellular Vesicle: An Emerging Mediator of Intercellular Crosstalk in Lung Inflammation and Injury

Frontiers in Immunology
Heedoo LeeYang Jin

Abstract

Inflammatory lung responses are one of the characterized features in the pathogenesis of many lung diseases, including acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD). Alveolar macrophages (AMs) and alveolar epithelial cells are the first line of host defense and innate immunity. Due to their central roles in both the initiation and resolution of inflammatory lung responses, AMs constantly communicate with other lung cells, including the alveolar epithelial cells. In the past, emerging evidence suggests that extracellular vesicles play an essential role in cell-cell crosstalk. In this review, we will discuss the recent findings on the intercellular communications between lung epithelial cells and alveolar macrophages, via EV-mediated signal transfer.

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Citations

Jun 6, 2020·Critical Reviews in Toxicology·Stéphanie AlkoussaPerrine J Martin
Sep 12, 2020·Journal of Cellular and Molecular Medicine·Stefanie HermannMichael W Pfaffl
Jun 17, 2020·Experimental & Molecular Medicine·Joshua Holtzman, Heedoo Lee
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Jul 23, 2020·Shock·Huiting ZhouJie Fan
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Jan 18, 2021·Life Sciences·Chaojin ChenZhiqiang Ye
Nov 8, 2020·Medical Sciences : Open Access Journal·Kareemah NiYang Jin
Mar 19, 2021·Journal of Extracellular Vesicles·Yuefei ZhangYuehai Ke
May 14, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yun TengHuang-Ge Zhang
May 1, 2021·Journal of Proteomics·Ryan T KendallCarol A Feghali-Bostwick
Apr 15, 2020·Journal of Innate Immunity·Sander van RietPadmini Khedoe

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Methods Mentioned

BETA
lavage
transmission electron microscopy
Transmission
atomic
bronchoalveolar lavage
AFM
GTPases
FACS

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