Extracellular Vesicles: A New Perspective in Tumor Therapy

BioMed Research International
Yan-Zi SunShao-Ming Wang

Abstract

In recent years, the study of extracellular vesicles has been booming across various industries. Extracellular vesicles are considered one of the most important physiological endogenous carriers for the specific delivery of molecular information (nucleonic acid, cytokines, enzymes, etc.) between cells. It has been discovered that they perform a critical role in promoting tumor cell growth, proliferation, tumor cell invasion, and metastatic ability and regulating the tumor microenvironment to promote tumor cell communication and metastasis. In this review, we will discuss (1) the mechanism of extracellular vesicles generation, (2) their role in tumorigenesis and cancer progression (cell growth and proliferation, tumor microenvironment, epithelial-mesenchymal transition (EMT), invasion, and metastasis), (3) the role of extracellular vesicles in immune therapy, (4) extracellular vesicles targeting in tumor therapy, and (5) the role of extracellular vesicles as biomarkers. It is our hope that better knowledge and understanding of the extracellular vesicles will offer a wider range of effective therapeutic targets for experimental tumor research.

References

May 31, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Elodie RistorcelliAlain Verine
Oct 3, 2008·Cancer Research·Brian D LehmannDavid M Terrian
Dec 8, 2009·Nature Cell Biology·Matias OstrowskiClotilde Thery
Nov 30, 2010·Molecular and Cellular Neurosciences·Gaelle LachenalRémy Sadoul
May 2, 2012·International Journal of Rheumatology·Chenjie Yang, Paul D Robbins
Feb 27, 2013·The Journal of Biological Chemistry·Nobuyoshi KosakaTakahiro Ochiya
Dec 24, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Chai San HoNoor Hasima
Jan 28, 2014·Translational Oncology·W Tris ArscottKevin A Camphausen
Aug 2, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Luisa PascucciAugusto Pessina
Nov 3, 2015·Nature·Ayuko HoshinoDavid Lyden
Nov 26, 2015·The Journal of Biological Chemistry·Anurag PurushothamanRalph D Sanderson
Aug 6, 2016·Biochemical and Biophysical Research Communications·Jiyeon KimSoon Ae Kim
Nov 4, 2016·Nature Reviews. Molecular Cell Biology·Johannes SchönebergJames H Hurley
Jan 14, 2017·Biomaterials·Eunee KohIn-San Kim
Apr 17, 2017·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ulrich SterzenbachJason Howitt
May 22, 2017·Biochimica Et Biophysica Acta. General Subjects·Oliver D MrowczynskiJames R Connor
Jun 11, 2017·Scientific Reports·Laia BonjochDaniel Closa
Jun 14, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiance JinCongying Xie
Jun 16, 2017·Journal of Cellular Physiology·Hamed MirzaeiMahmoud Reza Jaafari
Jun 25, 2017·Scientific Reports·Jing WangXiaoyi Huang
Jul 5, 2017·Molecular and Cellular Biology·Jiacong GuoWei Li

❮ Previous
Next ❯

Citations

Dec 16, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Yuan LiangJiang Du
Sep 24, 2020·Current Topics in Medicinal Chemistry·Le-Yi ZhangZhi-Ming Hu
Nov 10, 2020·Life Sciences·Md Nazim Uddin, Xiaosheng Wang
Aug 28, 2021·International Journal of Molecular Sciences·Dae D ChungRajesh C Miranda

❮ Previous
Next ❯

Methods Mentioned

BETA
gene rescue

Related Concepts