Extracellular vesicles and encapusulated miRNAs as emerging cancer biomarkers for novel liquid biopsy

Japanese Journal of Clinical Oncology
Yusuke YoshiokaTakahiro Ochiya

Abstract

Over the past several years, considerable focus has been placed on the need for 'biomarkers'. However, traditional biomarkers, such as CEA or CA19-9, for gastrointestinal cancer do not provide sufficient sensitivity and specificity for diagnosing cancer. Moreover, these biomarkers cannot provide information regarding the individual variability of patients. Recently, extracellular vesicles (EVs) and extracellular microRNA (miRNA) have shown potential in cancer diagnosis because tumor cells have been shown to release EVs and miRNAs, which mirror their cellular origin, into circulation. Therefore, detection of tumor-specific EVs and extracellular miRNA in body fluids from cancer patients could serve as a non-invasive liquid biopsy for cancer diagnosis and monitoring. This review explores the potential contribution of liquid biopsy using EVs and extracellular miRNA to diagnosis and monitor cancer, including an assessment of prognosis and early detection of disease recurrence in patients with cancer.

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Citations

Sep 12, 2019·Scientific Reports·Sirisha ThippabhotlaMei He
Oct 31, 2019·The Journal of Clinical Endocrinology and Metabolism·Alessia GrassoF Vilella
Jun 27, 2020·International Journal of Molecular Sciences·Akiko KogureTakahiro Ochiya
Nov 7, 2019·American Journal of Physiology. Cell Physiology·Fumihiko UrabeTakahiro Ochiya
Jan 10, 2021·Journal of Personalized Medicine·Beatriz C LopesDebora A P C Zuccari

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