Extracellular vesicles as biomarkers in liver diseases: A clinician's point of view.

Journal of Hepatology
Sara Thietart, Pierre-Emmanuel Rautou

Abstract

Extracellular vesicles are membrane-bound vesicles containing proteins, lipids, RNAs and microRNAs. They can originate from both healthy and stressed cells, and provide a snapshot of the cell of origin in physiological and pathological circumstances. Various processes that may give rise to the release of extracellular vesicles occur in liver diseases, including hepatocyte apoptosis, hepatic stellate cell activation, liver innate immune system activation, systemic inflammation, and organelle dysfunction (mitochondrial dysfunction and endoplasmic reticulum stress). Numerous studies have therefore investigated the potential role of extracellular vesicles as biomarkers in liver diseases. This review provides an overview of the methods that can be used to measure extracellular vesicle concentrations in clinical settings, ranging from plasma preparation to extracellular vesicle measurement techniques, as well as looking at the challenges of using extracellular vesicles as biomarkers. We also provide a comprehensive review of studies that test extracellular vesicles as diagnostic, severity and prognostic biomarkers in various liver diseases, including non-alcoholic and alcoholic steatohepatitis, viral hepatitis B and C infections, cir...Continue Reading

References

Aug 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·Trairak PisitkunMark A Knepper
Sep 17, 2004·Platelets·H ManiE Lindhoff-Last
Oct 1, 2010·Journal of Thrombosis and Haemostasis : JTH·E van der PolR Nieuwland
Oct 28, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Miroslaw KornekDetlef Schuppan
Nov 15, 2011·Journal of Immunological Methods·Muthuvel JayachandranWhyte G Owen
Nov 30, 2011·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Giuseppe LippiEmmanuel J Favaloro
Mar 8, 2012·Journal of Thrombosis and Haemostasis : JTH·E van der PolT G van Leeuwen
Apr 3, 2012·Gastroenterology·Pierre-Emmanuel RautouChantal M Boulanger
Jun 5, 2012·Frontiers in Physiology·Fatemeh Momen-HeraviWinston Patrick Kuo
Nov 6, 2012·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Michael C LarsonCheryl A Hillery
Dec 13, 2012·Transplantation·Moritz SchmelzleSimon C Robson
Feb 5, 2013·Expert Review of Hematology·Pierre-Emmanuel Rautou, Nigel Mackman
Feb 8, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R Todd StravitzDon A Gabriel
Jun 19, 2013·Biological Chemistry·Fatemeh Momen-HeraviWinston Patrick Kuo
Jul 19, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·H LiS Jie
Sep 7, 2013·Journal of Extracellular Vesicles·Kenneth W WitwerFred Hochberg
Sep 7, 2013·Journal of Extracellular Vesicles·Jason Webber, Aled Clayton
Jan 1, 2014·Journal of Extracellular Vesicles·Andrew F HillEsther N M Nolte-'t Hoen
Jan 21, 2014·Cancer Biomarkers : Section a of Disease Markers·Wenjie WangShenghua Jie
Jan 29, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pierre-Emmanuel RautouNigel Mackman
Feb 5, 2014·Nature Reviews. Gastroenterology & Hepatology·Sara LemoinnePierre-Emmanuel Rautou
Feb 6, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ling LiFlorin M Selaru
Mar 13, 2014·Journal of Thrombosis and Haemostasis : JTH·N ArraudA R Brisson
Jul 18, 2014·Molecular Biology Reports·Yanping Yang, Rui Zhu
Oct 4, 2014·Journal of Extracellular Vesicles·Anita N BöingRienk Nieuwland
Oct 16, 2014·Journal of Extracellular Vesicles·Jan Van DeunAn Hendrix
Nov 18, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Wayne L ChandlerHoward P Monsour
Dec 3, 2014·Biochemical and Biophysical Research Communications·Ziqing LiuJohnny J He
Feb 18, 2015·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Tom Groot KormelinkMarca H M Wauben
Feb 24, 2015·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Micah J Mooberry, Nigel S Key
Mar 15, 2015·Methods : a Companion to Methods in Enzymology·Douglas D Taylor, Sahil Shah
Apr 12, 2015·Journal of Extracellular Vesicles·Malene Møller JørgensenKim Varming
Jul 4, 2015·International Journal of Cancer. Journal International Du Cancer·Diederick DuijveszGuido Jenster

❮ Previous
Next ❯

Citations

Jan 13, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Elena CampelloPaolo Simioni
Dec 7, 2020·Journal of Hepatology·Delphine WeilVincent Di Martino
Dec 29, 2020·Frontiers in Endocrinology·Tim Hendrikx, Christoph J Binder
Jan 10, 2021·International Journal of Molecular Sciences·Vijay PandyarajanJu Dong Yang
Apr 4, 2021·Journal of Clinical Medicine·Alessia VirzìJoachim Lupberger
Jun 5, 2021·Advanced Drug Delivery Reviews·Enis KostallariPierre-Emmanuel Rautou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.