Extracellular Vesicles as Therapeutic Agents for Cardiac Fibrosis

Frontiers in Physiology
Russell G RogersAhmed Ibrahim

Abstract

Heart disease remains an increasing major public health challenge in the United States and worldwide. A common end-organ feature in diseased hearts is myocardial fibrosis, which stiffens the heart and interferes with normal pump function, leading to pump failure. The development of cells for regenerative therapy has been met with many pitfalls on its path to clinical translation. Recognizing that regenerative cells secrete therapeutically bioactive vesicles has paved the way to circumvent many failures of cell therapy. In this review, we provide an overview of extracellular vesicles (EVs), with a focus on their utility as therapeutic agents for cardiac regeneration. We also highlight the engineering potential of EVs to enhance their therapeutic application.

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Citations

Mar 30, 2021·Advanced Drug Delivery Reviews·Matthew A BorrelliSteven R Little
Apr 9, 2021·Advanced Drug Delivery Reviews·Maximilian RichterGregor Fuhrmann
Aug 28, 2021·Frontiers in Cardiovascular Medicine·Selvaraj JayaramanKanagaraj Palaniyandi

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Methods Mentioned

BETA
size exclusion chromatography

Software Mentioned

ExoCarta

Related Concepts

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Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.

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