Extracellular vesicles extracted from young donor serum attenuate inflammaging via partially rejuvenating aged T-cell immunotolerance

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Weikan WangDong-Ming Su

Abstract

Biologic aging results in a chronic inflammatory condition, termed inflammaging, which establishes a risk for such age-related diseases as neurocardiovascular diseases; therefore, it is of great importance to develop rejuvenation strategies that are able to attenuate inflammaging as a means of intervention for age-related diseases. A promising rejuvenation factor that is present in young blood has been found that can make aged neurons younger; however, the component in the young blood and its mechanism of action are poorly elucidated. We assessed rejuvenation in naturally aged mice with extracellular vesicles (EVs) or exosomes extracted from young murine serum on the basis of different spectrums of microRNAs in these vesicles from young and old sera. We found that EVs extracted from young donor mouse serum, rather than EVs extracted from old donor mouse serum or non-EV supernatant extracted from young donor mouse serum, were able to attenuate inflammaging in old mice. Inflammaging is attributed to multiple factors, one of which is thymic aging-released self-reactive T cell-induced pathology. We found that the attenuation of inflammaging after treatment with EVs from young serum partially contributed to the rejuvenation of thymi...Continue Reading

References

Jul 27, 2000·Annals of the New York Academy of Sciences·C FranceschiG De Benedictis
Oct 24, 2000·Immunological Reviews·N Baumgarth
Apr 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H S AzzamP E Love
Nov 5, 2002·Annual Review of Immunology·Timothy K StarrKristin A Hogquist
Nov 25, 2003·Scandinavian Journal of Immunology·B NakkenA D Farris
Jun 24, 2004·Nature Reviews. Genetics·Lin He, Gregory J Hannon
Sep 17, 2004·Nature·Victor Ambros
May 21, 2005·Immunity & Ageing : I & a·Federico LicastroCalogero Caruso
Nov 23, 2006·Mechanisms of Ageing and Development·Claudio FranceschiStefano Salvioli
Dec 19, 2006·Immunity & Ageing : I & a·Sergio Giunta
Sep 18, 2007·Neurobiology of Aging·Andrew J Farrall, Joanna M Wardlaw
Jun 6, 2009·Nature Reviews. Immunology·Clotilde ThéryElodie Segura
Jun 9, 2009·Current Opinion in Immunology·Mario F Fraga
Sep 1, 2009·Ageing Research Reviews·Vincenzo CalvaneseMario F Fraga
Dec 4, 2009·The Journal of Biological Chemistry·Lili ChengDong-Ming Su
Apr 13, 2010·Molecular Cell·Liang WuYijun Qi
May 7, 2010·Trends in Molecular Medicine·Adam FreundJudith Campisi
May 25, 2010·Biochimica Et Biophysica Acta·Marilena V IorioCarlo M Croce
Aug 24, 2010·Ageing Research Reviews·Stefan BrunnerBeatrix Grubeck-Loebenstein
Nov 26, 2010·Current Opinion in Genetics & Development·Judith Campisi
May 25, 2011·The Journal of Experimental Medicine·Amy E MoranKristin A Hogquist
Jun 8, 2011·Traffic·Angélique BobrieClotilde Théry
Jan 10, 2012·Cell Stem Cell·Julia M RuckhRobin J M Franklin
Feb 11, 2012·Aging Cell·María Berdasco, Manel Esteller
Apr 27, 2012·Rejuvenation Research·Iryna PishelGennadij Butenko
May 29, 2012·Seminars in Immunology·Kevin P HighJanko Nikolich-Zugich
Oct 9, 2012·Mechanisms of Ageing and Development·Fabiola OlivieriAntonio Domenico Procopio
Dec 4, 2012·Autoimmunity Reviews·Saul A Villeda, Tony Wyss-Coray
Jan 22, 2013·Proteomics·Takeshi KatsudaTakahiro Ochiya
May 22, 2013·Ageing Research Reviews·Fabiola OlivieriClaudio Franceschi
Jun 28, 2013·Frontiers in Genetics·Fabiola OlivieriFrancesca Fazioli
Feb 28, 2014·Frontiers in Immunology·Paola de CandiaSergio Abrignani
Apr 10, 2014·Development·Nicholas BredenkampC Clare Blackburn

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Citations

Sep 27, 2018·Frontiers in Immunology·Minwen XuLiefeng Wang
Jan 15, 2021·Immunity & Ageing : I & a·L DuongC Jackaman
Jan 28, 2021·International Journal of Molecular Sciences·Ju Hun SuhJung Min Lee
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tahereh FarkhondehSaeed Samarghandian
May 1, 2021·Biomedicines·Melanie A KimmMoritz Wildgruber
May 7, 2021·Mechanisms of Ageing and Development·Debasish Kumar Dey, Sun Chul Kang
Jun 4, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Laura R Goldberg
Jun 12, 2021·Frontiers in Immunology·Mingli LuoXi Sun
Jun 14, 2021·Free Radical Biology & Medicine·Ionara Rodrigues SiqueiraLaura Reck Cechinel
Aug 8, 2021·International Journal of Molecular Sciences·Ainhoa AlberroDavid Otaegui
Aug 26, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Antero Salminen

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