Extracellular vesicles from patients with Acute Coronary Syndrome impact on ischemia-reperfusion injury.

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Fabrizio D'AscenzoMaria F Brizzi

Abstract

The relevance of extracellular vesicles (EV) as mediators of cardiac damage or recovery upon Ischemia Reperfusion Injury (IRI) and Remote Ischemic PreConditioning (RIPC) is controversial. This study aimed to investigate whether serum-derived EV, recovered from patients with Acute Coronary Syndrome (ACS) and subjected to the RIPC or sham procedures, may be a suitable therapeutic approach to prevent IRI during Percutaneous-Coronary-Intervention (PCI). A double-blind, randomized, sham-controlled study (NCT02195726) has been extended, and EV were recovered from 30 patients who were randomly assigned (1:1) to undergo the RIPC- (EV-RIPC) or sham-procedures (EV-naive) before PCI. Patient-derived EV were analyzed by TEM, FACS and western blot. We found that troponin (TnT) was enriched in EV, compared to healthy subjects, regardless of diagnosis. EV-naive induced protection against IRI, both in-vitro and in the rat heart, unlike EV-RIPC. We noticed that EV-naive led to STAT-3 phosphorylation, while EV-RIPC to Erk-1/2 activation in the rat heart. Pre-treatment of the rat heart with specific STAT-3 and Erk-1/2 inhibitors led us to demonstrate that STAT-3 is crucial for EV-naive-mediated protection. In the same model, Erk-1/2 inhibition re...Continue Reading

References

Jul 16, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Zhi-Qing ZhaoJakob Vinten-Johansen
Feb 14, 2004·Cardiovascular Research·Stephen C Armstrong
Sep 11, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Derek J HausenloyDerek M Yellon
May 10, 2005·Cardiovascular Research·Alexander BrillDavid Varon
Jul 23, 2005·Circulation Research·Alexandre D T CostaStuart D Critz
Sep 28, 2005·Circulation·Patrick StaatMichel Ovize
Aug 26, 2006·Nature Clinical Practice. Cardiovascular Medicine·Hiroshi Ito
Sep 15, 2007·The New England Journal of Medicine·Derek M Yellon, Derek J Hausenloy
Mar 26, 2009·Journal of Molecular and Cellular Cardiology·Sandrine Lecour
Jun 9, 2009·Cardiovascular Research·David Garcia-DoradoHans Michael Piper
Aug 15, 2012·Autophagy·Xiucui MaAbhinav Diwan
Sep 12, 2012·Journal of Cardiovascular Medicine·Karin Przyklenk, Peter Whittaker
Jan 21, 2014·Journal of Molecular and Cellular Cardiology·Zoltán GiriczPéter Ferdinandy
May 16, 2014·Journal of Molecular and Cellular Cardiology·Xiaohong WangGuo-Chang Fan
Jul 26, 2014·Basic Research in Cardiology·Jing LiAndrew N Redington
Jan 2, 2015·Dose-response : a Publication of International Hormesis Society·Peter Whittaker, Karin Przyklenk
Feb 24, 2015·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Micah J Mooberry, Nigel S Key
Aug 13, 2015·Organic & Biomolecular Chemistry·Xabier OsteikoetxeaEdit Irén Buzás
Sep 29, 2015·Journal of Atherosclerosis and Thrombosis·Shosaku Nomura
Jan 9, 2016·The Journal of Endocrinology·Charlotte LawsonSean M Davidson
Feb 5, 2016·Nature Reviews. Cardiology·Derek J Hausenloy, Derek M Yellon
Mar 29, 2016·Basic Research in Cardiology·K E O'SullivanJ P Hurley
Jun 9, 2016·Cytokine·Daniel J GaramaDaniel J Gough
Oct 22, 2016·Basic Research in Cardiology·Derek J HausenloyDavid Garcia-Dorado
Dec 28, 2016·International Journal of Molecular Medicine·Maria Chiara DeregibusGiovanni Camussi

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