Extracellular vesicles in breast cancer drug resistance and their clinical application

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Shentong YuJian Zhang

Abstract

Drug resistance currently represents a daunting challenge in the treatment of breast cancer patients. With an increased understanding of the underlying mechanisms of drug resistance, the role of extracellular vesicles (EVs) in the development of chemo-insensitivity attracts extensive attention. EVs are membrane-limited, cell type-dependent vesicles that are secreted by normal or malignant cells. EVs comprise various types of contents, including genetic cargoes, proteins, and specific lipids. The characteristics of the contents determine their specific functions in not only physiological but also pathological conditions. It has been demonstrated that miRNAs and proteins in EVs are strongly correlated with breast cancer drug resistance. Additionally, they may exert an influence on de novo and acquired resistance bioprocesses. With the advances in extraction and detection technologies, EVs have also been employed to precisely diagnose and predict the outcome of therapy in breast cancer. On the other hand, they can also be exploited as efficient delivery system in future anticancer applications. In this paper, we summarized relative mechanisms concerning the relationship between EVs and breast cancer drug resistance, and then, we p...Continue Reading

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Citations

Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·G OcchipintiF Piva
Jan 17, 2017·International Journal of Cancer. Journal International Du Cancer·Brunna Dos Anjos PultzMarcelo José Barbosa Silva
Nov 21, 2017·Biomarkers in Medicine·Yunjie HeJinhai Tang
Dec 30, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sreerenjini LakshmiSulochana Priya
Mar 27, 2021·Frontiers in Molecular Biosciences·Zhu-Jun LawHui Poh Goh

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