Extracellular vesicles in cardiovascular homeostasis and disease

Current Opinion in Cardiology
Joshua D Hutcheson, Elena Aikawa

Abstract

Extracellular vesicles have emerged as one of the most important means through which cells interact with each other and the extracellular environment, but extracellular vesicle research remains challenging due to their small size, limited amount of material required for traditional molecular biology assays and inconsistency in the methods of their isolation. The advent of new technologies and standards in the field, however, have led to increased mechanistic insight into extracellular vesicle function. Herein, the latest studies on the role of extracellular vesicles in cardiovascular physiology and disease are discussed. Extracellular vesicles help control cardiovascular homeostasis and remodelling by mediating communication between cells and directing alterations in the extracellular matrix to respond to changes in the environment. The message carried from the parent cell to extracellular space can be intended for both local (within the same tissue) and distal (downstream of blood flow) targets. Pathological cargo loaded within extracellular vesicles could further result in various diseases. On the contrary, new studies indicate that injection of extracellular vesicles obtained from cultured cells into diseased tissues can pro...Continue Reading

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Citations

Jan 10, 2019·Frontiers in Cardiovascular Medicine·Mark C Blaser, Elena Aikawa
Jul 10, 2020·Skeletal Muscle·Laura Le GallStephanie Duguez
Nov 9, 2018·Frontiers in Cardiovascular Medicine·Manna LiJian Xu
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Sep 19, 2020·Journal of Extracellular Vesicles·Kristen PopowskiKe Cheng
Dec 10, 2020·International Journal of Molecular Sciences·Johannes OesterreicherWolfgang Holnthoner
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Aug 24, 2021·International Reviews of Immunology·Vijay KumarUdai P Singh
May 8, 2020·Ecotoxicology and Environmental Safety·Ling KongPeili Huang

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