Mar 26, 2020

Extracellular vesicles in the oligodendrocyte microenvironment

Neuroscience Letters
Eva-Maria Krämer-Albers


Extracellular vesicles (EVs) recently took centre stage as mediators of cellular crosstalk modulating the tissue microenvironment. Released by all types of neural cells, EVs may execute a broad spectrum of functions ranging from maintenance of neuronal homeostasis and regulation of neural plasticity to the spread of neurodegenerative agents. Myelinating oligodendrocytes and axons form a highly specialized functional entity that depends on intimate interactions within the oligodendrocyte-neuron niche. EVs released by oligodendrocytes are internalized by neurons in response to neuronal signals and exhibit neuroprotective properties but also may influence other cells present in the microenvironment. Here we discuss the role of EVs released by oligodendrocytes in regulating development, homeostatic maintenance and regeneration within the oligodendrocyte niche.

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Mentioned in this Paper

Neuronal Plasticity
Natural Regeneration
Regulation of Cell Development
Neurodegenerative Disorders
Oligodendrocyte Compact Myelin
Intercellular Communication Process
Neuron Homeostasis

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