Extracellular Vesicles in Viral Spread and Antiviral Response.

Viruses
Raquel Bello-MoralesJosé Antonio López-Guerrero

Abstract

Viral spread by both enveloped and non-enveloped viruses may be mediated by extracellular vesicles (EVs), including microvesicles (MVs) and exosomes. These secreted vesicles have been demonstrated to be an efficient mechanism that viruses can use to enter host cells, enhance spread or evade the host immune response. However, the complex interplay between viruses and EVs gives rise to antagonistic biological tasks-to benefit the viruses, enhancing infection and interfering with the immune system or to benefit the host, by mediating anti-viral responses. Exosomes from cells infected with herpes simplex type 1 (HSV-1) may transport viral and host transcripts, proteins and innate immune components. This virus may also use MVs to expand its tropism and evade the host immune response. This review aims to describe the current knowledge about EVs and their participation in viral infection, with a specific focus on the role of exosomes and MVs in herpesvirus infections, particularly that of HSV-1.

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Citations

Dec 4, 2020·International Journal of Molecular Sciences·José Antonio López-GuerreroRaquel Bello-Morales
Oct 27, 2020·Medicine in Drug Discovery·Ernesto Estrada
Aug 28, 2020·Current Opinion in Virology·Ryan P McNamara, Dirk P Dittmer
Dec 16, 2020·Cancers·Kevin Ho Wai YimRichard Chahwan
May 11, 2021·Frontiers in Immunology·Yury O Nunez LopezRichard E Pratley
Jun 14, 2021·Free Radical Biology & Medicine·Ionara Rodrigues SiqueiraLaura Reck Cechinel
Jul 17, 2021·Annual Review of Cell and Developmental Biology·Adeline KervielNihal Altan-Bonnet

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Methods Mentioned

BETA
bronchoalveolar lavage
GTPase

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