PMID: 9538934Apr 16, 1998Paper

Extracellulary administered lysophosphatidylcholine causes Ca2+ efflux from freshly isolated adult rat cardiomyocytes

Basic Research in Cardiology
K ItohI Katoh

Abstract

It has previously been reported that ischemia and reperfusion of the heart cause accumulation of lysophosphatidylcholine (LPC) within the myocardium. While it is known that LPC causes the transient increase of intracellular free Ca2+ concentration ([Ca2+]i) during contraction of cardiac cells, little is known about the mechanism for decreasing [Ca2+]i in cardiomyocytes during LPC accumulation. Since cumulative elevation in [Ca2+]i leads to irreversible injury to cardiomyocytes, elevated [Ca2+]i must be restored to an unstimulated level to maintain cell functions. In the present study, we therefore examined the effect of LPC on Ca2+ efflux from freshly isolated adult rat cardiomyocytes. LPC stimulated the efflux of 45Ca2+ from the cells in a concentration-dependent manner (10(-7)M-10(-5)M). Other lysophospholipids, which are generated from phospholipids of the cell membrane, failed to induce 45Ca2+ efflux from the cells. Dilazep and K-7259, which are known to inhibit the increase in [Ca2+]i caused by LPC, likewise reduced 45Ca2+ efflux caused by LPC addition. Furthermore, the LPC-stimulated 45Ca2+ efflux was not affected by removal of extracellular Ca2+, but was dependent on the presence of extracellular Na+. On the other hand, ...Continue Reading

Citations

Sep 24, 2004·The Journal of Membrane Biology·H A Wilson-AshworthJ D Bell
Jun 15, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·J HademH Drexler
Nov 12, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Ozan UnsalanRui Fausto
Mar 27, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·I H Lambert, B Falktoft
Jul 7, 2011·International Journal of Molecular Sciences·María S GimenezNidia N Gomez
Jan 30, 2007·Journal of the American College of Cardiology·Jun SuzukiWilbur Y W Lew
Oct 18, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K M LawrenceD S Latchman
Apr 10, 2004·American Journal of Physiology. Heart and Circulatory Physiology·P Michael GrossmanMark R Starling
Apr 3, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Julio Altamirano, Donald M Bers
Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kenneth ChristopherDavid L Perkins
Jul 15, 2003·Journal of Applied Physiology·Bradley M PalmerRussell L Moore

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