Extracorporeal carbon dioxide removal for acute hypercapnic exacerbations of chronic obstructive pulmonary disease: study protocol for a randomised controlled trial

Trials
Nicholas A BarrettLuigi Camporota

Abstract

Chronic obstructive pulmonary disease (COPD) is a common cause of chronic respiratory failure and its course is punctuated by a series of acute exacerbations which commonly lead to hospital admission. Exacerbations are managed through the application of non-invasive ventilation and, when this fails, tracheal intubation and mechanical ventilation. The need for mechanical ventilation significantly increases the risk of death. An alternative therapy, extracorporeal carbon dioxide removal (ECCO2R), has been shown to be efficacious in removing carbon dioxide from the blood; however, its impact on respiratory physiology and patient outcomes has not been explored. A randomised controlled open label trial of patients (12 in each arm) with acute exacerbations of COPD at risk of failing conventional therapy (NIV) randomised to either remaining on NIV or having ECCO2R added to NIV with a primary endpoint of time to cessation of NIV. The change in respiratory physiology following the application of ECCO2R and/or NIV will be measured using electrical impedance tomography, oesophageal pressure and parasternal electromyography. Additional outcomes, including patient tolerance, outcomes, need for readmission, changes in blood gases and biochem...Continue Reading

Associated Clinical Trials

Mar 13, 2014·Nicholas Barrett

References

Sep 1, 1986·Psychophysiology·A J Fridlund, J T Cacioppo
Sep 28, 1995·The New England Journal of Medicine·L BrochardF Lemaire
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·T A SeemungalJ A Wedzicha
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·C SinderbyP Sliwinski
Aug 14, 2001·American Journal of Respiratory and Critical Care Medicine·R E KannerUNKNOWN Lung Health Study Research Group
Jan 30, 2003·Thorax·J Garcia-AymerichUNKNOWN Estudi del Factors de Risc d'Agudització de la MPOC investigators
May 31, 2003·Journal of Medical Engineering & Technology·B H Brown
Jun 11, 2003·The European Respiratory Journal. Supplement·S Burge, J A Wedzicha
Nov 1, 1960·Journal of Applied Physiology·J M PETITL DELHEZ
Jun 5, 2004·The European Respiratory Journal·S SpencerP W Jones
Feb 3, 2005·The European Respiratory Journal·M ConfalonieriUNKNOWN Italian noninvasive positive pressure ventilation (NPPV) study group
Jun 27, 2006·Intensive Care Medicine·Alexandre DemouleLaurent Brochard
Jul 13, 2006·Annual Review of Biomedical Engineering·R H Bayford
Oct 31, 2006·Critical Care : the Official Journal of the Critical Care Forum·Sergio LivigniGuido Bertolini
Sep 24, 2008·Intensive Care Medicine·Thomas RiedelUrs Frey
Sep 30, 2008·Thorax·Terence SeemungalUNKNOWN ICEAD Contributors
Dec 31, 2008·Critical Care Medicine·Marc BodensteinKlaus Markstaller
Feb 4, 2009·Current Opinion in Critical Care·Eduardo L V CostaMarcelo B P Amato
Jun 11, 2009·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Victor J CardenasJoseph B Zwischenberger
May 7, 2010·Current Opinion in Critical Care·Thomas MudersChristian Putensen
Jun 1, 2009·European Respiratory Review : an Official Journal of the European Respiratory Society·C J Jolley, J Moxham
Oct 20, 2010·European Respiratory Review : an Official Journal of the European Respiratory Society·A Anzueto
Apr 12, 2011·Current Opinion in Critical Care·Onnen MoererMichael Quintel
Apr 20, 2011·Thorax·Joerg SteierJohn Moxham
Sep 20, 2011·The Journal of Thoracic and Cardiovascular Surgery·Jose P GarciaBartley P Griffith
Oct 22, 2011·American Journal of Respiratory and Critical Care Medicine·Divay ChandraFernando Holguín
Aug 11, 2012·American Journal of Respiratory and Critical Care Medicine·Jørgen VestboRoberto Rodriguez-Roisin

❮ Previous
Next ❯

Citations

Dec 27, 2019·Current Opinion in Critical Care·Elena SpinelliTommaso Mauri
Aug 4, 2020·Seminars in Respiratory and Critical Care Medicine·Óscar PeñuelasJordi Mancebo

❮ Previous
Next ❯

Software Mentioned

Draeger EIT Data Analysis Tool

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.