Extracorporeal life support for severe acute respiratory distress syndrome in adults

Annals of Surgery
Mark HemmilaRobert H Bartlett

Abstract

Severe acute respiratory distress syndrome (ARDS) is associated with a high level of mortality. Extracorporeal life support (ECLS) during severe ARDS maintains oxygen and carbon dioxide gas exchange while providing an optimal environment for recovery of pulmonary function. Since 1989, we have used a protocol-driven algorithm for treatment of severe ARDS, which includes the use of ECLS when standard therapy fails. The objective of this study was to evaluate our experience with ECLS in adult patients with severe ARDS with respect to mortality and morbidity. We reviewed our complete experience with ELCS in adults from January 1, 1989, through December 31, 2003. Severe ARDS was defined as acute onset pulmonary failure, with bilateral infiltrates on chest x-ray, and PaO2/fraction of inspired oxygen (FiO2) ratio < or =100 or A-aDO2 >600 mm Hg despite maximal ventilator settings. The indication for ECLS was acute severe ARDS unresponsive to optimal conventional treatment. The technique of ECLS included veno-venous or veno-arterial vascular access, lung "rest" at low FiO2 and inspiratory pressure, minimal anticoagulation, and optimization of systemic oxygen delivery. During the study period, ECLS was used for 405 adult patients age 17 ...Continue Reading

References

Nov 16, 1979·JAMA : the Journal of the American Medical Association·W M ZapolR G Miller
Apr 1, 1987·The American Review of Respiratory Disease·R S SimmonsW G Johanson
May 1, 1986·Chest·R H BartlettH Pontoppidan
Jan 1, 1993·Critical Care Medicine·J C ParkerK J Peevy
Apr 28, 1993·JAMA : the Journal of the American Medical Association·L GattinoniR Fumagalli
Sep 1, 1996·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·M MachaS M Pham
Mar 1, 1997·The Journal of Clinical Investigation·L TremblayA S Slutsky
Feb 5, 1998·The New England Journal of Medicine·M B AmatoC R Carvalho
Apr 29, 1998·Journal of Critical Care·P B RichR H Bartlett
Jun 25, 1998·American Journal of Respiratory and Critical Care Medicine·A S Slutsky, L N Tremblay
Jul 21, 1998·JAMA : the Journal of the American Medical Association·G U MeduriE A Tolley
Jul 31, 1998·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·P B RichR H Bartlett
Oct 10, 1998·The Journal of Thoracic and Cardiovascular Surgery·P B RichR J Schreiner
Jun 1, 1999·Current Opinion in Pediatrics·M R Hemmila, R B Hirschl
Feb 24, 2000·JAMA : the Journal of the American Medical Association·R H BartlettR B Hirschl
Feb 29, 2000·Journal of Pediatric Surgery·F SwanikerR Hirschl
May 4, 2000·The New England Journal of Medicine·UNKNOWN Acute Respiratory Distress Syndrome NetworkArthur Wheeler
Dec 6, 2000·The Journal of Surgical Research·S S AwadR H Bartlett
Jul 4, 2001·The Journal of Thoracic and Cardiovascular Surgery·N G SmediraD M Cosgrove
Feb 19, 2002·American Journal of Respiratory and Critical Care Medicine·Andrew D BerstenUNKNOWN Australian and New Zealand Intensive Care Society Clinical Trials Group
Jun 5, 2002·The Journal of Trauma·Andrew J MichaelsWilliam B Long
Aug 29, 2003·The Journal of Surgical Research·Preston B RichRichard C Boucher
Nov 7, 2003·The Annals of Thoracic Surgery·Nikoleta S KolovosThomas J Kulik

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Citations

Jul 29, 2006·Intensive Care Medicine·Martin BeiderlindenJürgen Peters
Sep 22, 2009·Intensive Care Medicine·Thomas V BroganSusan L Bratton
Aug 7, 2010·Intensive Care Medicine·Christian KaragiannidisThomas Mueller
Mar 28, 2012·General Thoracic and Cardiovascular Surgery·Tomohito SadahiroKoichiro Shinozaki
Feb 26, 2013·General Thoracic and Cardiovascular Surgery·Hiromasa NakamuraTatsuya Nakao
Jun 28, 2011·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Daniele CamboniThomas Müller
Jun 6, 2006·International Journal of Clinical Practice·Y-K HuangP J Lin
May 22, 2010·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Adriano PerisGian Franco Gensini
Dec 19, 2009·Critical Care : the Official Journal of the Critical Care Forum·Thomas MüllerMatthias Lubnow
May 8, 2010·Critical Care : the Official Journal of the Critical Care Forum·David J WallaceArthur Boujoukos
Jul 20, 2011·Journal of Emergencies, Trauma, and Shock·I A HamidN R Ravi Shankar
Oct 23, 2013·Heart, Lung & Circulation·Gökhan LafçOmer Faruk Cicek
Sep 4, 2014·Intensive Care Medicine·Ken Parhar, Alain Vuylsteke
Oct 19, 2012·Medizinische Klinik, Intensivmedizin und Notfallmedizin·T Staudinger
Jul 17, 2008·Chest·Douglas J E SchuererCraig M Coopersmith
Jul 8, 2010·Chest·Anand ChockalingamKevin C Dellsperger
Jul 6, 2013·Journal of Critical Care·Kiran ShekarJohn F Fraser
Jun 9, 2010·Chest·Suhail RaoofCurtis N Sessler
Mar 20, 2015·Chest·James M BlumCraig M Coopersmith
May 7, 2013·Annales Françaises D'anesthèsie Et De Rèanimation·D RogerG Lebreton
Jan 2, 2013·Journal of Cardiothoracic and Vascular Anesthesia·Patrick N OdonkorAlina M Grigore
Aug 28, 2012·Critical Care Nursing Clinics of North America·Ronald E DechertWaseem Ostwani
Nov 26, 2011·The Annals of Thoracic Surgery·David J SpurlockJonathan W Haft
Sep 20, 2011·The Journal of Thoracic and Cardiovascular Surgery·Jose P GarciaBartley P Griffith
Jul 12, 2011·Critical Care Clinics·Pauline K ParkRobert H Bartlett
Aug 21, 2010·The Journal of Thoracic and Cardiovascular Surgery·David Sanchez-LorentePaolo Macchiarini
Apr 20, 2010·Anesthesiology Clinics·James M BlumLauryn R Rochlen

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