Extracorporeal liver support devices for listed patients

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Karla C L LeeR Jalan

Abstract

An alternative to liver transplantation for patients with liver failure remains an unmet need. In acute liver failure, the ideal extracorporeal liver support device (ELSD) would replace the functions of the failing liver in order to permit spontaneous recovery, given the incredible regenerative potential of the liver, negating the need for transplantation. In acute-on-chronic liver failure, an ELSD would ideally support hepatic function until a recovery to liver function before acute decompensation or until liver transplantation. In decompensated cirrhosis, an ELSD could again be used to support hepatic function until transplant. In addition, ELSDs may have the potential to treat the multiorgan failure that accompanies liver failure including hepatic encephalopathy, renal failure, and immune dysfunction or indeed potential to promote liver regeneration. Creation of an extracorporeal bioartificial liver able to completely replace liver function remains an unmet need. This review will describe a number of technologies suitable for clinical trials in humans, which have resulted from decades of engineering and biological research to develop a bioreactor able to adequately sustain functional hepatocytes. In addition, this review wil...Continue Reading

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Citations

Oct 27, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Rajiv Jalan
Oct 16, 2016·Journal of Pediatric Gastroenterology and Nutrition·Riad LutfiGirish Subbarao
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Oct 15, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Emma C Alexander, Akash Deep
Oct 27, 2021·Seminars in Dialysis·Etienne Macedo, Jorge Cerdá

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