Extracorporeal photochemotherapy in systemic sclerosis and severe morphea

Dermatology : International Journal for Clinical and Investigative Dermatology
B CribierE Grosshans

Abstract

Extracorporeal photochemotherapy (EP) is a new immune-modulating therapy which combines cytapheresis and extracorporeal irradiation of leukocytes by UVA. Recently, patients with systemic sclerosis (SS) have been treated by this method, but the efficacy of EP is still controversial. Our purpose was to evaluate the efficacy and safety of EP in SS and in severe morphea. In an open study, 7 patients with SS and 2 patients with severe morphea were treated by EP and were evaluated after 6 months of treatment. No other treatments were allowed during this period. Except one vasovagal reaction, EP was well tolerated in all patients. The surface of the cutaneous sclerosis was unchanged in 3 of the 7 patients with SS, whereas it was aggravated in the remaining 4 patients. There was no improvement of the visceral involvement of SS in these patients. Although the duration of SS was less than 4 years in 6 out of 7 patients, we did not observe any significant benefit from EP in SS patients. One patient with generalized morphea had stopped EP after 3 months because of loss of vascular access and could not be evaluated. In the last patient with linear morphea of the upper limbs, a reduction in the number of morphea plaques was observed, and the...Continue Reading

Citations

Oct 6, 1997·Clinics in Dermatology·M A de Rie, J D Bos
May 1, 2001·International Journal of Dermatology·G G Russo, C Mullen
Aug 17, 2010·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·E MerlinF Deméocq
Oct 18, 2001·The Journal of Dermatology·M MaedaY Kitajima
May 17, 2012·Expert Opinion on Biological Therapy·Massimo MartinoGiuseppe Bresolin
Dec 17, 2009·Annales de dermatologie et de vénéréologie·C MorruzziD Lipsker
Nov 18, 2014·The British Journal of Dermatology·E A Gordon SprattJ A Brauer
Jan 17, 2007·Journal of the American Academy of Dermatology·Stefanie ReichAlexander Kreuter
May 18, 2004·Photodermatology, Photoimmunology & Photomedicine·M El-MoftyG El-Enani
Nov 16, 2005·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Stefanie ReichKlaus Hoffmann
Jun 30, 2012·Dermatologic Therapy·Alexander Kreuter
Sep 13, 2006·Clinics in Dermatology·Lorinda ChungDavid Fiorentino
Nov 21, 1997·Journal of the American Academy of Dermatology·M M SeygerE M de Jong
Aug 15, 1998·Journal of the American Academy of Dermatology·M M SeygerE M de Jong
Feb 19, 2000·Rheumatic Diseases Clinics of North America·M D Mayes
Apr 12, 2005·Pediatric Clinics of North America·Francesco Zulian
Dec 30, 2014·Journal of Clinical Apheresis·Zoya KuzminaSteven Z Pavletic
Mar 25, 1998·Seminars in Cutaneous Medicine and Surgery·N HunzelmannT Krieg
May 4, 2017·Current Rheumatology Reports·Xiaolong Alan Zhou, Jaehyuk Choi
Apr 25, 2018·The Journal of Dermatology·Yoshihide AsanoHironobu Ihn
Jul 31, 2019·Dermatology : International Journal for Clinical and Investigative Dermatology·Amy X DuRobert Gniadecki

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