Extracorporeal photopheresis, a therapeutic option for cutaneous T-cell lymphoma and immunological diseases: state of the art

Expert Opinion on Biological Therapy
Massimo MartinoGiuseppe Bresolin

Abstract

Extracorporeal photopheresis (ECP) has been extensively used for the treatment of immune-mediated diseases for over 20 years and has a consistent and predictable safety profile with long-term use. Documenting the efficacy of ECP as therapeutic treatment has long been a matter of importance for physicians. The authors reviewed publications in this field with the goal of providing an overview of this therapeutic approach. ECP is efficacious in a high percentage of those cutaneous T-cell lymphoma patients who have circulating malignant T cells in the context of a still-near-normal immune competence. From the side of graft-versus-host disease (GVHD), the use of ECP showed a clinical benefit in patients with steroid-refractory acute GVHD (aGVHD) and it is believed that ECP deserves to be evaluated as part of a combination strategy in first-line therapy of aGVHD. In chronic GHVD, the published data show that ECP can be effective in extensive and long-standing disease even when treatment is initiated at an advanced stage after conventional immunosuppressive and corticosteroid therapy has failed. ECP should be considered most beneficial for patients with predominantly mucocutaneous chronic GVHD. The fields of application of the procedu...Continue Reading

References

May 1, 1992·Journal of the American Academy of Dermatology·G LiangF A Kerdel
Dec 30, 1991·Annals of the New York Academy of Sciences·R L Edelson
Jun 1, 1991·Arthritis and Rheumatism·S E MalawistaR L Edelson
Feb 15, 1990·Annals of Internal Medicine·A H RookR L Edelson
Feb 5, 1987·The New England Journal of Medicine·R EdelsonG Plewig
Aug 1, 1980·The American Journal of Medicine·H M ShulmanE D Thomas
Aug 1, 1995·Journal of Photochemistry and Photobiology. B, Biology·A C MoorF P Gasparro
Jan 1, 1994·Archives of Dermatological Research·B PrinzG Plewig
Sep 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G I FegerM Wahl
Jun 1, 1993·International Journal of Dermatology·F X Di SpaltroE Bisaccia
Jan 1, 1993·Journal of the American Academy of Dermatology·H P GollnickC E Orfanos
Sep 1, 1995·The British Journal of Dermatology·J L MillerD L Ellis
Jan 1, 1995·Dermatology : International Journal for Clinical and Investigative Dermatology·B CribierE Grosshans
Oct 1, 1996·Journal of the American Academy of Dermatology·M DuvicN A Lemak
Mar 1, 1997·The British Journal of Dermatology·K B GordonD T Woodley
Jun 1, 1997·British Journal of Haematology·R Dall'AmicoG Zacchello
Apr 29, 1998·Journal of the American Academy of Dermatology·H I RichterJ Krutmann
Jun 11, 1998·Dermatology : International Journal for Clinical and Investigative Dermatology·C C ZouboulisC E Orfanos
Jun 11, 1998·Dermatology : International Journal for Clinical and Investigative Dermatology·K KrasagakisC E Orfanos
Mar 18, 1999·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·J A ZicL E King
Apr 3, 1999·Journal of the American Academy of Dermatology·B PrinzG Plewig
May 13, 1999·Journal of the American Academy of Dermatology·G MohlaS Stevens
May 15, 1999·Dermatology : International Journal for Clinical and Investigative Dermatology·U WollinaA Looks
May 25, 1999·Bone Marrow Transplantation·F J ChildR Russell-Jones
Oct 28, 1999·The Journal of Investigative Dermatology. Symposium Proceedings·A H RookS R Lessin
Nov 26, 1999·Journal of the American Academy of Dermatology·D N EnomotoJ D Bos
Nov 26, 1999·Journal of the American Academy of Dermatology·K R SuchinA H Rook
Jun 17, 2000·Transplantation Proceedings·A R TamburM D Tharp
Mar 17, 2001·International Journal of Cancer. Journal International Du Cancer·C L BergerR L Edelson

❮ Previous
Next ❯

Citations

Oct 2, 2014·The Journal of Clinical Investigation·Jason A DubovskyBruce R Blazar
Apr 16, 2013·Clinical Transplantation·J Rodrigo Diaz-SisoStefan G Tullius

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.