Extracorporeal Photopheresis-An Overview

Frontiers in Medicine
Ara ChoRobert Knobler

Abstract

Extracorporeal photopheresis (ECP) has been in clinical use for over three decades after receiving FDA approval for the palliative treatment of the Sézary Syndrome variant of cutaneous T-cell lymphoma (CTCL) in 1988. After the first positive experiences with CTCL, additional indications have been successfully explored including areas such as graft-vs.-host disease (GVHD), scleroderma, and solid organ transplantation. The mechanism of action is still not fully resolved, but important steps in understanding ECP in recent years have been very informative. Originally, the primary hypothesis stated that psoralen and ultraviolet A (UVA) in combination induce apoptosis in the treated immune cells. This view shifted in favor of dendritic cell initiation, modification of the cytokine profile and stimulation of several T-cell lineages, in particular regulatory T-cells. A number of ECP guidelines have been produced to optimize treatment regimens in the clinical context. In CTCL, enough evidence is available for the use of ECP as a first line treatment for Sézary Syndrome (SS), but also as a second line or rescue treatment in therapy-refractory forms of mycosis fungoides (MF). ECP in the treatment of acute and chronic GVHD has shown promis...Continue Reading

Associated Clinical Trials

Feb 12, 2021·Ulrike Blume-Peytavi, MD, Ulrike Blume-Peytavi, MD

References

Apr 1, 1992·Transplantation·M R Costanzo-NordinJ A Robinson
Mar 17, 1988·The New England Journal of Medicine·P F BougneresJ L Chaussain
Feb 5, 1987·The New England Journal of Medicine·R EdelsonG Plewig
Jan 1, 1994·Archives of Dermatological Research·B PrinzG Plewig
Jun 1, 1993·International Journal of Dermatology·F X Di SpaltroE Bisaccia
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Jan 1, 1997·Archives of Dermatological Research·M FimianiL Andreassi
Jan 1, 1997·Dermatology : International Journal for Clinical and Investigative Dermatology·M FimianiL Andreassi
Apr 29, 1998·Journal of the American Academy of Dermatology·H I RichterJ Krutmann
Jun 11, 1998·Dermatology : International Journal for Clinical and Investigative Dermatology·K KrasagakisC E Orfanos
Apr 3, 1999·Journal of the American Academy of Dermatology·B PrinzG Plewig
May 13, 1999·Journal of the American Academy of Dermatology·G MohlaS Stevens
Oct 29, 2000·Dermatology : International Journal for Clinical and Investigative Dermatology·A GerberH Gollnick
Mar 17, 2001·International Journal of Cancer. Journal International Du Cancer·C L BergerR L Edelson
Jul 24, 2001·Archives of Disease in Childhood·J LudvigssonG Berlin
Jul 20, 2002·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Carole L BergerRichard L Edelson
Jul 20, 2002·Inflammatory Bowel Diseases·Jacques CosnesJean-Pierre Gendre
Mar 15, 2003·Acta Dermato-venereologica·Michael RadenhausenKlaus Hoffmann
Dec 23, 2003·Dermatologic Therapy·John A Zic
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Akira MaedaThomas Schwarz
Jun 24, 2005·The New England Journal of Medicine·Bart KeymeulenLucienne Chatenoud
Dec 13, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Alexandra H FilipovichMary E D Flowers
Mar 2, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·J K KirklinM Marques
Apr 26, 2006·Journal of the American Academy of Dermatology·Robert M KnoblerUNKNOWN Systemic Sclerosis Study Group
Sep 13, 2006·Leukemia & Lymphoma·Michael GirardiRichard L Edelson
Jan 17, 2007·Journal of the American Academy of Dermatology·Stefanie ReichAlexander Kreuter
Feb 23, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Zhimin ZhaiYiping Wang
Aug 9, 2007·Dermatology : International Journal for Clinical and Investigative Dermatology·Michael SandKlaus Hoffmann
Oct 24, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Peter C ButlerAnil Bhushan
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Akira MaedaAgatha Schwarz
May 28, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·James F GeorgeJames K Kirklin

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Citations

Aug 19, 2020·Journal of Clinical Apheresis·Amy P Gabbard, Garrett S Booth
Oct 9, 2019·Nature Reviews. Clinical Oncology·Oliver KeppGuido Kroemer
Nov 22, 2019·World Journal of Transplantation·Maurizio Salvadori, Aris Tsalouchos
May 20, 2020·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·Mirjana Ziemer, Konstantin Dumann
Jun 26, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Samran HaiderAyman O Soubani
Jan 5, 2021·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·H StegeC Hünefeld
Feb 9, 2021·Expert Review of Anticancer Therapy·Suzanne Xu, Francine Foss
Dec 23, 2020·Journal of the American Academy of Dermatology·David M WeinerAlain H Rook
Oct 20, 2020·Clinical and Experimental Immunology·H HacksteinG Bein
Feb 6, 2021·Pharmaceutics·Taku FujimuraSetsuya Aiba
May 4, 2021·Photodiagnosis and Photodynamic Therapy·Dan YangHongxia Dan
May 25, 2021·Seminars in Respiratory and Critical Care Medicine·Olawale AmubieyaS Samuel Weigt
May 25, 2021·Seminars in Respiratory and Critical Care Medicine·Laura P Halverson, Ramsey R Hachem
Jun 8, 2021·HemaSphere·Lukas M Braun, Robert Zeiser
Jun 21, 2021·Advanced Drug Delivery Reviews·Alice GrangierAmanda K A Silva
Jun 17, 2021·Photochemistry and Photobiology·Maurício S BaptistaAndrés H Thomas
Sep 28, 2021·Current Treatment Options in Oncology·Caitlin M BrumfielAaron R Mangold
Jul 1, 2020·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Pablo Augusto Vieyra-Garcia, Peter Wolf
Jul 22, 2020·International Archives of Allergy and Immunology·Malgorzata BobrowiczEmmanuella Guenova

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Methods Mentioned

BETA
leukocyte collection
chromosomal aberrations
biopsies

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