Extracorporeal shock waves modulate myofibroblast differentiation of adipose-derived stem cells

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Letizia RinellaMaria Graziella Catalano

Abstract

Mesenchymal stem cells are precursors of myofibroblasts, cells deeply involved in promoting tissue repair and regeneration. However, since myofibroblast persistence is associated with the development of tissue fibrosis, the use of tools that can modulate stem cell differentiation toward myofibroblasts is central. Extracorporeal shock waves are transient short-term acoustic pulses first employed to treat urinary stones. They are a leading choice in the treatment of several orthopedic diseases and, notably, they have been reported as an effective treatment for patients with fibrotic sequels from burn scars. Based on these considerations, the aim of this study is to define the role of shock waves in modulating the differentiation of human adipose-derived stem cells toward myofibroblasts. Shock waves inhibit the development of a myofibroblast phenotype; they down-regulate the expression of the myofibroblast marker alpha smooth muscle actin and the extracellular matrix protein type I collagen. Functionally, stem cells acquire a more fibroblast-like profile characterized by a low contractility and a high migratory ability. Shock wave treatment reduces the expression of integrin alpha 11, a major collagen receptor in fibroblastic cell...Continue Reading

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Citations

Jun 4, 2016·Cell and Tissue Research·Tripp LeavittMichael T Longaker
Dec 18, 2016·Journal of Orthopaedic Surgery and Research·Marco ViganòLaura de Girolamo
Jan 11, 2018·Connective Tissue Research·Letizia RinellaMaria Graziella Catalano
Aug 25, 2020·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Antonino Di StefanoMaria Graziella Catalano

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