Extracorporeal therapy requirements for patients with acute renal failure.

Journal of the American Society of Nephrology : JASN
W R ClarkW L Macias

Abstract

Renal replacement therapy (RRT) requirements for critically ill patients with acute renal failure (ARF) depend on numerous factors, including the degree of hypercatabolism, patient size, and desired level of metabolic control. However, the current practice at many institutions is to prescribe generally similar amounts of RRT to ARF patients essentially without regard for the above factors. In this study, a computer-based model designed to permit individualized RRT prescription to ARF patients was developed. The critical input parameter is the desired level of metabolic control, which is the time-averaged BUN (BUNa) or steady-state BUN (BUNs) for intermittent hemodialysis (IHD) or continuous RRT (CRRT), respectively. The basis for the model was a group of 20 patients who received uninterrupted CRRT for at least 5 days. In these patients, the normalized protein catabolic rate (nPCR) increased linearly (r = 0.974) from 1.55 +/- 0.14 g/kg per day (mean +/- SEM) on day 1 to 1.95 +/- 0.15 g/kg per day on day 6. The daily urea generation rate (G), determined from the above linear relationship, was utilized to produce BUN versus time curves by the direct quantification method for simulated patients of varying dry weights (50 to 100 kg)...Continue Reading

Citations

Oct 27, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·N LameireR Vanholder
Oct 27, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·N S Kanagasundaram, E P Paganini
Jan 12, 2000·Current Opinion in Nephrology and Hypertension·A N Friedman, B L Jaber
May 5, 2020·Expert Review of Anti-infective Therapy·Soo Min JangBruce A Mueller
Apr 16, 2002·Seminars in Dialysis·Nele Van de NoortgateNorbert Lameire
Jul 12, 2002·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·Hideki Kawanishi
Apr 22, 2011·Journal of Pharmacy Practice·Michael L Bentley
Nov 28, 2002·Current Opinion in Critical Care·Patrick T MurrayCiro Tetta
Mar 18, 2003·Journal of Critical Care·Garth Hanson, Louise Moist
Mar 23, 2007·The International Journal of Artificial Organs·Z HuangC Ronco
May 24, 2007·The International Journal of Artificial Organs·S UchinoUNKNOWN Beginning and Ending Supportive Therapy for the Kidney (B.E.S.T. Kidney) Investigators Writing Committee
Feb 27, 2004·Journal of Intensive Care Medicine·Geoffrey S TeehanBertrand L Jaber
Aug 28, 2003·Artificial Organs·Zhijie LiaoDayong Gao
Aug 28, 2003·Artificial Organs·William R ClarkDayong Gao
Nov 25, 2003·Kidney International·Nigel S KanagasundaramUNKNOWN Project for the Improvement of the Care of Acute Renal Dysfunction (PICARD) Study Group
Nov 26, 2003·Current Opinion in Critical Care·W Van BiesenN Lameire
Oct 1, 2004·Hemodialysis International·Zhongping HuangWilliam R Clark
Mar 26, 2005·Seminars in Nephrology·Ramesh VenkataramanJohn A Kellum
Jun 11, 2002·Critical Care Clinics·Omaran Abdeen, Ravindra L Mehta
Mar 25, 2008·Therapeutics and Clinical Risk Management·Neesh Pannu, Rt Noel Gibney
Jul 10, 2003·Critical Care Clinics·Norma J Maxvold, Timothy E Bunchman
Jan 29, 2000·Critical Care Clinics·M M Meyer
Dec 5, 2006·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Hideki Kawanishi
Dec 31, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·L GarredB Canaud
Dec 31, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·W R ClarkW L Macias
Sep 2, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R D SwartzF K Port
Sep 2, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S BrunetJ Cardinal
May 12, 2009·Seminars in Dialysis·Kevin W Finkel, Amber S Podoll
Jun 16, 2010·Neurocritical Care·Pritesh PatelL Keith Scott
Jan 14, 2004·Seminars in Dialysis·Valerie A Luyckx, Joseph V Bonventre
Dec 1, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Rolando Claure-Del GranadoRavindra L Mehta
Feb 4, 2011·Organogenesis·Geoffrey M Fleming

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