Extracorporeally induced ablation of renal tissue by high-intensity focused ultrasound

BJU International
Axel HäckerPeter Alken

Abstract

To investigate the safety and the effects on healthy renal tissue of high-intensity focused ultrasound (HIFU) applied extracorporeally. Ultrasound waves (1.04 MHz) created by a cylindrical piezo-ceramic element were focused by a parabolic reflector to a physical focus size of 32 x 4 mm (-6 dB). For an in vivo study, HIFU was applied to the healthy tissue of 24 kidneys, monitored by ultrasonography, with a maximum power of 400 W and a spatially averaged intensity (ISAL) in the focus of 1192 W/cm(2). Fourteen kidneys were removed immediately after ablation to evaluate the side-effects and the effects in the focal zone, and 10 kidneys were removed delayed after 1, 7 and 10 days. The clinical study consisted of 19 patients requiring radical nephrectomy for a renal tumour. HIFU was applied to the healthy tissue of 19 kidneys (up to 1600 W, I(SAL) = 4768 W/cm(2)) before proceeding with the radical nephrectomy. There were no major complications after applying HIFU to the 43 kidneys. Side-effects included skin burns (grade 3) in two patients. During the follow-up there were no further HIFU-specific side-effects. In one case (in vivo study) there was a thermal lesion of the small intestine, which was due to mis-focusing. HIFU effects in...Continue Reading

References

Jan 1, 1993·European Urology·G VallancienJ Bougaran
Sep 23, 2003·The British Journal of Radiology·J E KennedyD Cranston
Feb 22, 2005·BJU International·Michael MarbergerJ E Kennedy
Nov 20, 1942·The Journal of General Physiology·J G LynnA E Miller

❮ Previous
Next ❯

Citations

Apr 25, 2007·Der Urologe. Ausg. A·H C Klingler
Feb 24, 2010·World Journal of Urology·Mesut RemziMehmet Ozsoy
Dec 17, 2009·Medical & Biological Engineering & Computing·Khaldon LweesyMohammad Sameer
Jan 30, 2013·Computers in Biology and Medicine·R H Abhilash, Sunita Chauhan
May 8, 2007·Nature Clinical Practice. Urology·Jason Hafron, Jihad H Kaouk
Apr 28, 2010·Journal of Endourology·Riccardo AutorinoJihad H Kaouk
Jan 15, 2011·Journal of Endourology·Joseph A GraversenJaime Landman
Jul 14, 2012·Journal of Endourology·Jonathan D HarperLawrence A Crum
Dec 6, 2006·Ultrasound Quarterly·Thomas A Leslie, James E Kennedy
Jan 10, 2009·Advances in Urology·Jose Rubio BrionesEduardo Solsona Narbón
Dec 4, 2009·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Adam C Mues, Jaime Landman
Dec 1, 2010·Indian Journal of Urology : IJU : Journal of the Urological Society of India·G NabiA Melzer
Dec 1, 2010·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Branden G Duffey, J Kyle Anderson
Mar 3, 2011·Medical Physics·C MougenotC Moonen
Jul 23, 2014·Current Opinion in Urology·Peter WagstaffM Pilar Laguna
Aug 19, 2007·European Radiology·Baudouin Denis de SennevilleChrit T W Moonen
Jan 16, 2010·AJNR. American Journal of Neuroradiology·O EsnaultL Leenhardt
Nov 5, 2014·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Ezekiel Maloney, Joo Ha Hwang
Jun 21, 2007·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·T A Leslie, J E Kennedy
Jul 20, 2012·Urologic Oncology·Riccardo Autorino, Jihad H Kaouk
May 2, 2009·The Urologic Clinics of North America·Gino J VricellaJeffrey A Cadeddu
Dec 20, 2008·The Journal of Urology·Marcelo A OrvietoArieh Shalhav
Jun 30, 2007·Seminars in Roentgenology·Michael BelandDebra A Gervais
Mar 3, 2007·Cancer Treatment Reviews·Eric C NelsonPrimo N Lara
Mar 17, 2010·BJU International·Robert W RitchieDavid Cranston
Jan 15, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·Masaki KimuraThomas J Polascik
Sep 26, 2007·Expert Review of Anticancer Therapy·David D Thiel, Howard N Winfield
Sep 7, 2016·The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS·George SagiasChristakis Damianou
Jun 21, 2011·Korean journal of urology·Seo Yeon LeeSeong Il Seo
Feb 4, 2009·Current Opinion in Urology·Tobias Klatte, Michael Marberger
May 31, 2017·Physics in Medicine and Biology·J M M van BreugelM G Ries
Mar 7, 2019·European Radiology Experimental·Simon MatooriJohannes M Froehlich

❮ Previous
Next ❯

Related Concepts

Related Feeds

Absence Epilepsy

Absence epilepsy is a common seizure disorder in children which can produce chronic psychosocial sequelae. Discover the latest research on absence epilepsies here.