Extracorporeally irradiated autografts for the treatment of bone tumours: tips and tricks.

International Orthopaedics
Bart PoffynDirk Uyttendaele

Abstract

We retrospectively reviewed 107 patients with 108 malignant or locally aggressive bone tumours treated between 1978 and 2009 by extracorporeal irradiation with 300 Gy to eradicate the tumour, and reimplantation of the bone as an orthotopic autograft. Patient subgroups were defined according to resection type. We describe the local recurrence rate, the graft infection rate and the factors affecting graft healing and graft survival. No local recurrences were detected in the irradiated grafts. At five-year follow-up, graft healing had occurred in 64% of patients, providing a stable and lasting reconstruction. For various reasons, 11% of grafts were removed, although no single factor was predictive of failure. All patient subgroups had comparable results. Early infection predicted the development of pseudarthrosis. Pelvic reconstructions had a worse graft survival. Rigid fixation and bridging of the graft appeared to be important technical points.

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Citations

Dec 27, 2013·Indian Journal of Cancer·D N SharmaA Kumar
Aug 1, 2015·The Bone & Joint Journal·S GuptaA Mahendra
Nov 19, 2015·Journal of Orthopaedic Surgery and Research·Jielai YangQingcheng Yang
Apr 29, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Takaaki Arahira, Mitsugu Todo
Feb 5, 2015·Case Reports in Orthopedics·Calogero GraciKorhan Ozkan
Nov 22, 2014·Journal of Neurosurgery·Daryoush TavanaiepourKeith Neiderer
Aug 26, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Takaaki Arahira, Mitsugu Todo
Sep 27, 2016·Journal of Oral Science·Kosaku SawadaReinhard Gruber
Oct 25, 2016·Journal of the Mechanical Behavior of Biomedical Materials·S ChauhanA Prasad
Jun 28, 2018·Journal of Surgical Oncology·Ajay PuriSiddharth Laskar
Nov 17, 2016·Journal of Korean Neurosurgical Society·Tae-Kyum KimUng-Kyu Chang

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