Extract from Aphloia theiformis, an edible indigenous plant from Reunion Island, impairs Zika virus attachment to the host cell surface

Scientific Reports
Elodie ClainChaker El-Kalamouni

Abstract

The mosquito-borne Zika virus (ZIKV) belongs to the flavivirus genus of the Flaviviridae family. Contemporary epidemic strains of ZIKV are associated with congenital malformations in infants, including microcephaly, as well as Guillain-Barré syndrome in adults. A risk of human-to-human transmission of ZIKV is also well documented. A worldwide research effort has been undertaken to identify safe and effective strategies to prevent or treat ZIKV infection. We show here that extract from Aphloia theiformis, an edible endemic plant from Indian Ocean islands, exerts a potent antiviral effect against ZIKV strains of African and Asian lineages, including epidemic strains. The antiviral effect of A. theiformis extract was extended to clinical isolates of dengue virus (DENV) of the four serotypes in human hepatocytes. A. theiformis inhibited virus entry in host cells by acting directly on viral particles, thus impairing their attachment to the cell surface. Electron microscopic observations revealed that organization of ZIKV particles was severely affected by A. theiformis. We propose a model of antiviral action for A. theiformis against flaviviruses that highlights the potential of medicinal plants as promising sources of naturally-der...Continue Reading

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Citations

May 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dovilė GrauzdytėPetras Rimantas Venskutonis
Jun 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vanessa Shi Li GohJustin Jang Hann Chu
May 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Juliano G HaddadChaker El Kalamouni
Sep 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Juliano G HaddadChaker El Kalamouni
Sep 5, 2019·Pharmaceuticals·Juan-Carlos Saiz

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Datasets Mentioned

BETA
AF226687
HG235027
KU513442
LC002520

Methods Mentioned

BETA
flow cytometry
confocal microscopy
transmission electron microscopy
PCR

Software Mentioned

NIS
- Pad Prism
Zen2
CytExpert
Element AR
Graph

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