Extract of Ascaris suum induces TGF-β and early production of IgG1 in experimental autoimmune hepatitis

Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária
Roeckson Carlos Peixoto SilvaValdênia Maria Oliveira de Souza

Abstract

In experimental autoimmune hepatitis (EAH) of Th1 profile, an extract of adult Ascaris suum worms (ASC) was previously found to deviate the immune response to a Th2/IL-10 pattern. Here, the effects of treatment with ASC on production of TGF-β and the anti-Ascaris isotypes IgG1 and IgG2a in EAH were evaluated. EAH was induced in BALB/c mice, intravenously with concanavalin A. Two hours later, these animals received ASC (EAH+ASC group) or PBS vehicle (EAH group). IgG1 and IgG2a were evaluated 8 h, 24 h and 7 d after induction. TGF-β was measured in a splenocyte culture at this last time. The isotype levels in the EAH group were low throughout the kinetics. In the EAH+ASC group, there was significant production of IgG1 at 24 h and 7 d, but of IgG2a only at 7 d. There was statistically greater production of TGF-β in the EAH+ASC group. The higher levels of IgG1 and TGF-β in this group suggest that an additional Th1 response control route exists in EAH, which needs to be investigated.

References

Jul 1, 1992·The Journal of Clinical Investigation·G TiegsA Wendel
May 1, 1995·Cellular Immunology·A P FerreiraM S Macedo
Dec 18, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·V M O SouzaM S Macedo
Mar 24, 2005·Infection and Immunity·Laurence U Buxbaum, Phillip Scott
Jun 29, 2006·International Archives of Allergy and Immunology·Aldacilene S SilvaMahasti S Macedo
Jan 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Annette ErhardtGisa Tiegs
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hua-Xing WeiZhigang Tian
Nov 4, 2010·Scandinavian Journal of Immunology·C A A de AraújoM F Macedo-Soares
Jun 22, 2014·Parasitology Research·Wheverton C NascimentoValdênia O Souza
Jul 31, 2018·Journal of Immunology Research·Marion Rolot, Benjamin G Dewals
Nov 27, 2018·Frontiers in Immunology·Ana Clara Gazzinelli-GuimarãesRicardo Toshio Fujiwara

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.