Extract of Rhus verniciflua stokes protects the diet-induced hyperlipidemia in mice

Archives of Pharmacal Research
Se-Jin JeongGoo Taeg Oh

Abstract

Rhus verniciflua stokes (RVS) is a popular medicinal plant in oriental medicines which is commonly used to resolve extravasated blood. To elucidate the molecular mechanism of the role of RVS extracts on the regulation of lipid and cholesterol biosynthesis, we investigated whether RVS extract protect the hyperlipidemia in western diet-induced C57BL6/J mice. Mice fed a western diet and additionally RVS extracts was administered orally at a dose of 0.1 or 1 g/kg/day for 2 weeks respectively. Group with higher dose of RVS extract showed a significantly decreased body weight compared with western diet fed mice groups. And total cholesterol, LDL-cholesterol levels and fatty liver formation were also improved especially in group of mice fed western diet supplemented high dose RVS extracts. Next, synthesis of hepatic bile acids were significantly increased in RVS extract fed groups. Furthermore, RVS extracts significantly increase promoter activity of Cyp7a1 via up-regulate the transcriptional expression level of LXRα. Our data suggest that RVS extracts could be a potent therapeutic ingredient for prevent a hyperlipidemia via increase of bile acids biosynthesis.

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Citations

Jun 6, 2017·Biological & Pharmaceutical Bulletin·Ramakanta LamichhaneHyun-Ju Jung
Feb 6, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Kyungho Kim, Kwang-Il Park
Nov 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wei LiHwan-Suck Chung
Dec 24, 2019·Acta Pharmaceutica Sinica. B·Yuhua LiHuichang Bi
Nov 19, 2020·Oxidative Medicine and Cellular Longevity·Young Soo KimJang-Gi Choi
Feb 26, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Prakash Raj PandeyaHyun-Ju Jung

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